DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and Fgr

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_077059.2	Gene:	Fgr / 79113	RGDID:	621319	Length:	517	Species:	Rattus norvegicus

Alignment Length:	403	Identity:	139/403 - (34%)
Similarity:	214/403 - (53%)	Gaps:	43/403 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   948 SLSTNRPLY-------------EEEWFHGVLPREEVVRLLNNDGD----FLVRETIRNEESQIVL 995
            |||:.|..|             .|||:.|.:.|::..|.|.:||:    ||:||:...:.:..:.
  Rat   107 SLSSGRTGYVPSNYVAPVDSIQAEEWYFGKISRKDAERQLLSDGNPQGAFLIRESETTKGAYSLS 171

  Fly   996 SVCWNGH-----KHFIVQTTGEGNFRF-EGPPFASIQELIMH--QYHSELPVTVKSGAILRRP-- 1050
            ...|:.:     ||:.::....|.:.. ....|.|:|:|:.|  :.:..|...:.:..::.:|
  Rat   172 IRDWDQNRGDHIKHYKIRKLDMGGYYITTRAQFESVQDLVRHYMEVNDGLCYLLTAPCMVMKPQT 236

  Fly  1051 --VCRERWELSNDDVVLLERIGRGNFGDVYKAKLK-STKLDVAVKTCRMTLPDEQKRK-FLQEGR 1111
              :.::.||:..:.:.|..|:|.|.||||:..... |||  |||||.:   |.....| ||:|.:
  Rat   237 LGLAKDAWEIDRNSIALDRRLGTGCFGDVWLGTWNCSTK--VAVKTLK---PGTMSPKAFLEEAQ 296

  Fly  1112 ILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLR-KNSNGLTTRQQMGMCRDAAAGMRY 1175
            |:|...|..:|:|..: |.::||.||.|.:..||||.:|: :..:.|.....:.|....|.||.|
  Rat   297 IMKLLRHDKLVQLYAV-VSEEPIYIVTEFMCYGSLLDFLKDRKGHNLMLPNLVDMAAQVAEGMAY 360

  Fly  1176 LESKNCIHRDLAARNCLVDLEHSV-KISDFGMSR--EEEEYIVSDGMKQIPVKWTAPEALNFGKY 1237
            :|..|.|||||.|.|.||. ||.: ||:|||::|  .::||....|.| .|:|||||||..||::
  Rat   361 MERMNYIHRDLRAANILVG-EHLICKIADFGLARLIVDDEYNPQQGTK-FPIKWTAPEAALFGRF 423

  Fly  1238 TSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAE 1302
            |...||||:|||:.|:.:||..||.||.|....|:::.||.||.|...|..:|.:|.|.|..|.|
  Rat   424 TVKSDVWSFGILLTELITKGRVPYPGMNNREVLEQVEHGYHMPCPPGCPVSLYEVMEQTWRLDPE 488

  Fly  1303 SRPHFDEIYNVVD 1315
            .||.|:.:.:.::
  Rat   489 ERPTFEYLQSFLE 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	25/110 (23%)
		TyrKc	1063..1311	CDD:197581	108/253 (43%)
		PTKc_Fes_like	1067..1315	CDD:270637	107/253 (42%)
Fgr	NP_077059.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	17..46
		SH3	68..125	CDD:418401	5/17 (29%)
		SH2_Src_Fgr	128..228	CDD:198230	23/99 (23%)
		PKc_like	255..502	CDD:419665	107/255 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910