DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and ptk6b

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001070140.1	Gene:	ptk6b / 767734	ZFINID:	ZDB-GENE-060929-1150	Length:	511	Species:	Danio rerio

Alignment Length:	463	Identity:	154/463 - (33%)
Similarity:	233/463 - (50%)	Gaps:	49/463 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   885 KP-VKPSVQISGHKDHPFESSSGELDENSDRDID---NDEEEEDSASDD--VLSMKDHCYCVPSL 943
            || :||.:..|.:.:.....:..:....:|:::.   .|:.|....|.|  ..:.||....|.:.
Zfish    53 KPKIKPPLPPSANNNAAIYMALWDFKARNDQELSFKAGDKFEITDRSGDWWTANKKDIFGRVTTG 117

  Fly   944 AASISLSTNRPLYEEEWFHGVLPREEVVRLL----NNDGDFLVRETIRNEESQIVLSV-CWNGHK 1003
            ....:......:..:.||.|.:.|...|..|    ||.|.||||.: .:::...|||| .....|
Zfish   118 FVPYNYLARDSVESQPWFFGKMNRVGAVSHLMSDENNYGSFLVRVS-ESDDMGYVLSVRTKENAK 181

  Fly  1004 HFIVQTTGEGNFRFEGPPFASIQELIMHQYHSELPVTVKSGAILRRPVCR-----------ERWE 1057
            ||.:..||:..:......|:||.|:|.| |.|. |:::  |.:|..|..|           :.||
Zfish   182 HFKIFQTGDQFYVDALFKFSSIVEVIEH-YQSH-PLSI--GDLLSEPCIRIKPENVPPPSTDEWE 242

  Fly  1058 LSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCR----MTLPDEQKRKFLQEGRILKQYDH 1118
            |..::..|..::|.|:|.|||..|.|:.. .||:|..:    :.|     |:|..|.:|:|:..|
Zfish   243 LPKEEFQLENQLGSGHFADVYSGKWKNHS-KVAIKILKNNDALVL-----REFQLEVQIMKRLRH 301

  Fly  1119 PNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQ--MGMCRDAAAGMRYLESKNC 1181
            .:::.|..:|....|..|:.||:..|.||.:|| |..|.:.:.:  :.|....|.||.|||:.|.
Zfish   302 KHLISLFAVCTSSSPFYIITELIEKGDLLHFLR-NPEGRSLQMESLIDMAAQVADGMAYLEANNS 365

  Fly  1182 IHRDLAARNCLVDLEHSVKISDFGMSR--EEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVW 1244
            |||||||||.||...:..||:|||::|  :|..|:..|  |:||.|||||||:..|.|:|..|||
Zfish   366 IHRDLAARNVLVGDGYVCKIADFGLARIIKEPVYLSDD--KKIPYKWTAPEAIGHGTYSSKSDVW 428

  Fly  1245 SYGILMWEIFSKGDTPYSGMTNSRARERI-DTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHF- 1307
            |:|||::||.:.|..||.|:......:.| ...||||:|...|:.:|.:|..||..::..||:|
Zfish   429 SFGILLYEIVTHGGIPYPGVNTGEVYDLITKENYRMPSPPKCPQAIYNIMRACWRIESVDRPNFK 493

  Fly  1308 ---DEIYN 1312
               ||:.|
Zfish   494 VLKDELDN 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	30/90 (33%)
		TyrKc	1063..1311	CDD:197581	102/260 (39%)
		PTKc_Fes_like	1067..1315	CDD:270637	102/259 (39%)
ptk6b	NP_001070140.1	SH3_Brk	70..126	CDD:212781	8/55 (15%)
		SH2	132..216	CDD:214585	31/86 (36%)
		PTKc_Srm_Brk	241..502	CDD:133248	106/270 (39%)
		STYKc	250..499	CDD:214568	101/257 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910