DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and ZAP70

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_016860356.1	Gene:	ZAP70 / 7535	HGNCID:	12858	Length:	742	Species:	Homo sapiens

Alignment Length:	558	Identity:	141/558 - (25%)
Similarity:	217/558 - (38%)	Gaps:	155/558 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   839 PC---KQCTKRRRIHPSKSVFDFAKEFEVE-------QPAGSAADEQFCNCPPAGQKPVKPSVQI 893
            ||   |.|.:...:.|...|||..::..|.       :..|.|.::...:..|    .|:..:..
Human   218 PCNLRKPCNRPSGLEPQPGVFDCLRDAMVRDYVRQTWKLEGEALEQAIISQAP----QVEKLIAT 278

  Fly   894 SGHKDHPFESSSGELDENSDRDIDNDEEEEDSASDDVLSMKDHCYCVPSLAASISLSTNRPLYEE 958
            :.|:..|
Human   279 TAHERMP---------------------------------------------------------- 285

  Fly   959 EWFHGVLPREEVVRLL----NNDGDFLVRETIRNEESQIVLSVCWNGH-KHFIVQTTGEGNFRF- 1017
             |:|..|.|||..|.|    ..||.||:|.  |.|:....||:.:... .|:::.....|.:..
Human   286 -WYHSSLTREEAERKLYSGAQTDGKFLLRP--RKEQGTYALSLIYGKTVYHYLISQDKAGKYCIP 347

  Fly  1018 EGPPFASIQELI----------MHQYHSELPVTVKSGA-------------ILRRPVCR------ 1053
            ||..|.::.:|:          ::......|.:..|.|             .|..|..|
Human   348 EGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAAPTLPAHPSTLTHPQRRIDTLNS 412

  Fly  1054 --------------------------------------ERWELSNDDVVLLE-RIGRGNFGDVYK 1079
                                                  ::..|..|::::.: .:|.||||.|.:
Human   413 DGYTPEPARITSPDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQ 477

  Fly  1080 A--KLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVL 1142
            .  :::..::|||:|..:.........:.::|.:|:.|.|:|.||:|||:| |.:.:|:|||:..
Human   478 GVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEMAG 541

  Fly  1143 GGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMS 1207
            ||.|..:|......:.......:....:.||:|||.||.:||||||||.|:...|..||||||:|
Human   542 GGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLS 606

  Fly  1208 R---EEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRA 1269
            :   .::.|..:....:.|:||.|||.:||.|::|..||||||:.|||..|.|..||..|.....
Human   607 KALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEV 671

  Fly  1270 RERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHF 1307
            ...|:.|.||..|...|.|:|.||..||....|.||.|
Human   672 MAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDF 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	23/101 (23%)
		TyrKc	1063..1311	CDD:197581	95/251 (38%)
		PTKc_Fes_like	1067..1315	CDD:270637	95/247 (38%)
ZAP70	XP_016860356.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910