DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and YES1

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_005424.1	Gene:	YES1 / 7525	HGNCID:	12841	Length:	543	Species:	Homo sapiens

Alignment Length:	383	Identity:	135/383 - (35%)
Similarity:	206/383 - (53%)	Gaps:	36/383 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   958 EEWFHGVLPREEVVRLLNNDGD----FLVRETIRNEESQIVLSVCW-----NGHKHFIVQTTGEG 1013
            |||:.|.:.|::..|||.|.|:    |||||:...:.:..:....|     :..||:.::....|
Human   156 EEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNG 220

  Fly  1014 NFRF-EGPPFASIQELIMH-QYHSE--------LPVTVKSGAILRRPVCRERWELSNDDVVLLER 1068
            .:.. ....|.::|:|:.| ..|::        :..|||...   :.:.::.||:..:.:.|..:
Human   221 GYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQT---QGLAKDAWEIPRESLRLEVK 282

  Fly  1069 IGRGNFGDVYKAKLKSTKLDVAVKTCR--MTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQK 1131
            :|:|.||:|:......| ..||:||.:  ..:|:    .||||.:|:|:..|..:|.|..: |.:
Human   283 LGQGCFGEVWMGTWNGT-TKVAIKTLKPGTMMPE----AFLQEAQIMKKLRHDKLVPLYAV-VSE 341

  Fly  1132 QPIMIVMELVLGGSLLTYLRKNSNG--LTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVD 1194
            :||.||.|.:..||||.:| |..:|  |...|.:.|....|.||.|:|..|.|||||.|.|.||.
Human   342 EPIYIVTEFMSKGSLLDFL-KEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVG 405

  Fly  1195 LEHSVKISDFGMSR--EEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKG 1257
            .....||:|||::|  |:.||....|.| .|:|||||||..:|::|...||||:|||..|:.:||
Human   406 ENLVCKIADFGLARLIEDNEYTARQGAK-FPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKG 469

  Fly  1258 DTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVD 1315
            ..||.||.|....|:::.|||||.|:..||.::.||..||..|.:.||.|:.|.:.::
Human   470 RVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLE 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	24/99 (24%)
		TyrKc	1063..1311	CDD:197581	105/253 (42%)
		PTKc_Fes_like	1067..1315	CDD:270637	105/253 (42%)
YES1	NP_005424.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..45
		SH3_Yes	94..151	CDD:212940
		SH2_Src_family	154..253	CDD:199827	24/96 (25%)
		PTKc_Yes	264..542	CDD:270654	108/272 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910