DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and limk1a

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001036156.1	Gene:	limk1a / 735292	ZFINID:	ZDB-GENE-061212-3	Length:	648	Species:	Danio rerio

Alignment Length:	413	Identity:	107/413 - (25%)
Similarity:	173/413 - (41%)	Gaps:	89/413 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   965 LPREEVVRLLNNDGDFLVRETIRNEESQIVLSVCWNGHKHFIVQTTGEGNFRFEG---------- 1019
            :|.:|:        |.|::||.|                  ::|.|.|.:...:|
Zfish   233 VPLDEI--------DLLIQETSR------------------LLQLTIEHDPHDQGPSVDHVDGGP 271

  Fly  1020 -----------PPFASIQEL----IMHQY---HSELPVTVKSGAILRRPVCRER--WELSN---- 1060
                       ||...|..|    |...|   .|....:..|...||:.:.|..  ..:||
Zfish   272 SPSGGPSPITRPPSQDISNLRSRIITRSYSIDKSPSSSSAPSPLSLRKDIGRSESLRGVSNRTHR 336

  Fly  1061 ----DDVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNI 1121
                .|::..|.:|.|.||...|...:.|. :|.|....:...:|.:|.||:|.::::..||||:
Zfish   337 IFRASDLIHGEVLGTGCFGQAIKVTHRETG-EVMVMKELIRFDEETQRTFLKEVKVMRCLDHPNV 400

  Fly  1122 VKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDL 1186
            :|.||:..:.:.:..:.|.:.||:|...::...:.....|::...:|.|:||.||.|.|.|||||
Zfish   401 LKFIGVLYKDKRLNFIAEYIKGGTLRDIIKNMDSNYPWGQRVSFAKDIASGMAYLHSMNIIHRDL 465

  Fly  1187 AARNCLVDLEHSVKISDFGMSR-----EEEEYIVSDGMKQIPV----KWTAPEALNFGKYTSLCD 1242
            .:.||||....||.::|||:||     ...|...:|..|:..|    .|.|||.::...|....|
Zfish   466 NSHNCLVRENKSVVVADFGLSRLMVEDRSVERRKADRRKRYTVVGNPYWMAPEMIHGKSYDEKVD 530

  Fly  1243 VWSYGILMWEIFSK--GDTPYSGMTNSRARERIDTGYRMPT------PKSTPEEMYRLMLQCWAA 1299
            ::|:||::.||..:  .|..|.    .||   :|.|.....      |...|...:.:...|...
Zfish   531 LFSFGIMLCEIIGRVNADPDYL----PRA---LDFGLNTAVFLEEHCPADCPAAFFPIAALCCDL 588

  Fly  1300 DAESRPHFDEIYNVVDALILRLD 1322
            |||.||.|.::.:.::.|.:.|:
Zfish   589 DAEKRPAFTKLESWLEDLKMHLE 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	18/101 (18%)
		TyrKc	1063..1311	CDD:197581	80/264 (30%)
		PTKc_Fes_like	1067..1315	CDD:270637	80/264 (30%)
limk1a	NP_001036156.1	LIM1_LIMK1	5..79	CDD:188846
		LIM	86..140	CDD:295319
		PDZ	164..254	CDD:278991	9/46 (20%)
		TyrKc	346..603	CDD:197581	80/264 (30%)
		STKc_LIMK1	349..610	CDD:271123	80/268 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910