DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and TYK2

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001372133.1	Gene:	TYK2 / 7297	HGNCID:	12440	Length:	1257	Species:	Homo sapiens

Alignment Length:	322	Identity:	105/322 - (32%)
Similarity:	155/322 - (48%)	Gaps:	36/322 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly  1020 PPFASI-QELIMHQYHSELPV-TVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDV----Y 1078
            |.|.:| ::|...|.|:...| ||...:....|....:..|..     :..:|.|:||.|    |
Human   927 PSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKK-----IRDLGEGHFGKVSLYCY 986

  Fly  1079 KAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQ--KQPIMIVMELV 1141
            ......|...||||..:.....:.:..:.||..||:...|.:|:|..|.|..  ::.:.:|||.|
Human   987 DPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYV 1051

  Fly  1142 LGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGM 1206
            ..|||..||.::|.||.  |.:...:....||.||.:::.|||||||||.|:|.:..|||.|||:
Human  1052 PLGSLRDYLPRHSIGLA--QLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGL 1114

  Fly  1207 SR---EEEEY--IVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYS---- 1262
            ::   |..||  :..||  ..||.|.|||.|...|:....||||:|:.::|:.:..|:..|
Human  1115 AKAVPEGHEYYRVREDG--DSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTK 1177

  Fly  1263 ----------GMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVV 1314
                      .||..|..|.::.|.|:|.|...|.|:|.||..||..:|..||.|:.:..::
Human  1178 FLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPIL 1239

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	6/19 (32%)
		TyrKc	1063..1311	CDD:197581	94/272 (35%)
		PTKc_Fes_like	1067..1315	CDD:270637	94/273 (34%)
TYK2	NP_001372133.1	FERM_F1	28..125	CDD:408179
		FERM_F2	143..266	CDD:408177
		Jak1_Phl	285..432	CDD:407742
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	335..366
		SH2	437..534	CDD:417686
		PKc_like	589..937	CDD:419665	3/9 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	610..629
		PTKc_Tyk2_rpt2	962..1244	CDD:270664	95/287 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810