DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and TXK

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_024309968.1	Gene:	TXK / 7294	HGNCID:	12434	Length:	530	Species:	Homo sapiens

Alignment Length:	408	Identity:	141/408 - (34%)
Similarity:	212/408 - (51%)	Gaps:	52/408 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   940 VPSLAASISLSTNRPLYEEEWFHGVLPREEVVRLL---NNDGDFLVRE-------TI-------R 987
            :||...:.:..||..:|  ||:|..:.|.:...||   :.:|.|:||:       ||       |
Human   135 IPSNYVTENKITNLEIY--EWYHRNITRNQAEHLLRQESKEGAFIVRDSRHLGSYTISVFMGARR 197

  Fly   988 NEESQIVLSVCWNGHKHFIVQTTGEGN-FRFEGPPFASIQELIMHQYHSELPVTVKSGAILRRPV 1051
            :.|:.|         ||:.::....|. :..|...|.||.|||.:..|:...:..:    ||.||
Human   198 STEAAI---------KHYQIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTR----LRYPV 249

  Fly  1052 -----C--------RERWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRMTLPDEQK 1103
                 |        .|:||:...::..::.||.|.||.|:..:.:| .:.||:|........|:
Human   250 GLMGSCLPATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRS-HIQVAIKAINEGSMSEE- 312

  Fly  1104 RKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRD 1168
             .|::|.:::.:..|..:|:|.|:|:|::|:.||.|.:..|.||.|||:|...|.....:.:|:|
Human   313 -DFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGKLRKEMLLSVCQD 376

  Fly  1169 AAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSRE--EEEYIVSDGMKQIPVKWTAPEA 1231
            ...||.|||....||||||||||||.....||||||||:|.  ::||:.|.|.| .|:||:.||.
Human   377 ICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAK-FPIKWSPPEV 440

  Fly  1232 LNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQC 1296
            ..|.||:|..||||:|:||||:|::|..|:...:|.:..|.|..|:|:..|...|..:|.:|..|
Human   441 FLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSC 505

  Fly  1297 WAADAESRPHFDEIYNVV 1314
            |....|.||.|.|:...|
Human   506 WHEKPEGRPTFAELLRAV 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	27/103 (26%)
		TyrKc	1063..1311	CDD:197581	101/249 (41%)
		PTKc_Fes_like	1067..1315	CDD:270637	102/250 (41%)
TXK	XP_024309968.1	SH3_TXK	88..142	CDD:212840	2/6 (33%)
		SH2_Tec_Txk	146..251	CDD:198261	33/119 (28%)
		PTKc_Tec_like	269..524	CDD:173637	102/259 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810