DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and TIE1

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_005415.1	Gene:	TIE1 / 7075	HGNCID:	11809	Length:	1138	Species:	Homo sapiens

Alignment Length:	497	Identity:	154/497 - (30%)
Similarity:	221/497 - (44%)	Gaps:	126/497 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   880 PPAGQKPVKP---SVQISGHKDHPFESSSGELDENSDRDIDNDEEEEDSASDDVLSMKDHCYCVP 941
            |.|...|:..   .||::|....|..             ||.|..||.|
Human   667 PEALPGPISKYVVEVQVAGGAGDPLW-------------IDVDRPEETS---------------- 702

  Fly   942 SLAASISLSTNRPLYE--------EEWFHGVLPREEVVRLLNN--DGDFLVRETIRNEE---SQI 993
            ::...::.|| |.|:.        .:|.:.|   ||  ..|.|  ..:..|:|:...||   .|:
Human   703 TIIRGLNAST-RYLFRMRASIQGLGDWSNTV---EE--STLGNGLQAEGPVQESRAAEEGLDQQL 761

  Fly   994 VLSV------------------------CWNGHKHFIVQTTGEGNFRFEGPPFASIQELIMHQYH 1034
            :|:|                        |.:..:.|..| :|.|            :|.|:....
Human   762 ILAVVGSVSATCLTILAALLTLVCIRRSCLHRRRTFTYQ-SGSG------------EETILQFSS 813

  Fly  1035 SELPVTVKSGAILRRPVCRE--------RWELSNDDVVLLERIGRGNFGDVYKAKLK--STKLDV 1089
            ..|.:|       |||..:.        .||    |:...:.||.||||.|.:|.:|  ..|::.
Human   814 GTLTLT-------RRPKLQPEPLSYPVLEWE----DITFEDLIGEGNFGQVIRAMIKKDGLKMNA 867

  Fly  1090 AVKTCRMTLPDEQKRKFLQEGRIL-KQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKN 1153
            |:|..:....:...|.|..|..:| |...||||:.|:|.|..:..:.|.:|....|:||.:|||:
Human   868 AIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKS 932

  Fly  1154 ---------------SNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISD 1203
                           ::.|::||.:....|||.||:||..|..|||||||||.||....:.||:|
Human   933 RVLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIAD 997

  Fly  1204 FGMSREEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSR 1268
            ||:||.||.| |...|.::||:|.|.|:||:..||:..||||:|:|:|||.|.|.|||.|||.:.
Human   998 FGLSRGEEVY-VKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAE 1061

  Fly  1269 ARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEI 1310
            ..|::..||||..|::..:|:|.||.|||......||.|.:|
Human  1062 LYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQI 1103

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	23/122 (19%)
		TyrKc	1063..1311	CDD:197581	109/266 (41%)
		PTKc_Fes_like	1067..1315	CDD:270637	109/262 (42%)
TIE1	NP_005415.1	ig	129..210	CDD:278476
		EGF_CA	227..256	CDD:238011
		EGF_2	315..344	CDD:285248
		ig	356..441	CDD:278476
		fn3	452..536	CDD:278470
		fn3	548..632	CDD:278470
		FN3	644..736	CDD:238020	21/103 (20%)
		PTKc_Tie1	836..1132	CDD:270671	112/273 (41%)
		TyrKc	839..1107	CDD:197581	109/266 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910