DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and TESK1

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_006276.2	Gene:	TESK1 / 7016	HGNCID:	11731	Length:	626	Species:	Homo sapiens

Alignment Length:	277	Identity:	75/277 - (27%)
Similarity:	133/277 - (48%)	Gaps:	29/277 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly  1061 DDVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLI 1125
            ||....|:||.|.|.:|||.:.:.:.   .|...:|......:...|:|.:::.:..||||::.:
Human    55 DDFHCAEKIGAGFFSEVYKVRHRQSG---QVMVLKMNKLPSNRGNTLREVQLMNRLRHPNILRFM 116

  Fly  1126 GICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARN 1190
            |:||.:..:..:.|.:.||: |..|..:...|:...::.:..|.|.|:|||.||...||||.::|
Human   117 GVCVHQGQLHALTEYMNGGT-LEQLLSSPEPLSWPVRLHLALDIARGLRYLHSKGVFHRDLTSKN 180

  Fly  1191 CLV---DLEHSVKISDFGMSREEEEYIVSDGMKQIPVK------WTAPEALNFGKYTSLCDVWSY 1246
            |||   |...:..:.|||::  |:..:..:|.::.|:.      |.|||.|....|....||:::
Human   181 CLVRREDRGFTAVVGDFGLA--EKIPVYREGARKEPLAVVGSPYWMAPEVLRGELYDEKADVFAF 243

  Fly  1247 GILMWEIFSK--GDTPYSGMTNSRARERIDTGYRMPTPKS-----TPEEMYRLMLQCWAADAESR 1304
            ||::.|:.::  .|..|...|.       |.|..:|..::     .|.....|.:.|...:..:|
Human   244 GIVLCELIARVPADPDYLPRTE-------DFGLDVPAFRTLVGDDCPLPFLLLAIHCCNLEPSTR 301

  Fly  1305 PHFDEIYNVVDALILRL 1321
            ..|.||...::.::.:|
Human   302 APFTEITQHLEWILEQL 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224
		TyrKc	1063..1311	CDD:197581	71/263 (27%)
		PTKc_Fes_like	1067..1315	CDD:270637	72/263 (27%)
TESK1	NP_006276.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41
		TyrKc	61..311	CDD:197581	72/262 (27%)
		PKc_TESK	63..318	CDD:271057	71/267 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	331..373
		Required for interaction with YWHAB. /evidence=ECO:0000250\|UniProtKB:Q63572	419..524
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	423..488
		Required for interaction with SPRED1 and SPRY2. Required for TESK1-mediated dephosphorylation of SPRY2 and SPRY2 inhibition of ERK phosphorylation. /evidence=ECO:0000250\|UniProtKB:Q63572	527..626
		Required for interaction with PARVA. /evidence=ECO:0000250\|UniProtKB:Q63572	527..624
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	529..564
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910