DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment FER and TEK

DIOPT Version :9

Sequence 1:NP_524288.3 Gene:FER / 41118 FlyBaseID:FBgn0000723 Length:1325 Species:Drosophila melanogaster
Sequence 2:NP_000450.3 Gene:TEK / 7010 HGNCID:11724 Length:1124 Species:Homo sapiens


Alignment Length:321 Identity:118/321 - (36%)
Similarity:170/321 - (52%) Gaps:40/321 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly  1023 ASIQELIMHQYHS---ELPVTVKSGAI-LRR-----------PVCRERWELSNDDVVLLERIGRG 1072
            |::|..:...:.:   |..|...||.: |.|           ||      |..:|:...:.||.|
Human   775 ANVQRRMAQAFQNVREEPAVQFNSGTLALNRKVKNNPDPTIYPV------LDWNDIKFQDVIGEG 833

  Fly  1073 NFGDVYKAKLK--STKLDVAVKTCRMTLPDEQKRKFLQEGRIL-KQYDHPNIVKLIGICVQKQPI 1134
            |||.|.||::|  ..::|.|:|..:.....:..|.|..|..:| |...||||:.|:|.|..:..:
Human   834 NFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYL 898

  Fly  1135 MIVMELVLGGSLLTYLRKN---------------SNGLTTRQQMGMCRDAAAGMRYLESKNCIHR 1184
            .:.:|....|:||.:|||:               ::.|:::|.:....|.|.||.||..|..|||
Human   899 YLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHR 963

  Fly  1185 DLAARNCLVDLEHSVKISDFGMSREEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGIL 1249
            ||||||.||...:..||:|||:||.:|.| |...|.::||:|.|.|:||:..||:..||||||:|
Human   964 DLAARNILVGENYVAKIADFGLSRGQEVY-VKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVL 1027

  Fly  1250 MWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEI 1310
            :|||.|.|.|||.|||.:...|::..|||:..|.:..:|:|.||.|||......||.|.:|
Human  1028 LWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQI 1088

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FERNP_524288.3 F-BAR_Fes_Fer 7..243 CDD:153341
SH2_Fps_family 953..1039 CDD:198224 3/18 (17%)
TyrKc 1063..1311 CDD:197581 106/266 (40%)
PTKc_Fes_like 1067..1315 CDD:270637 106/262 (40%)
TEKNP_000450.3 Ig_Tie2_1 24..118 CDD:402176
EGF_Lam 230..275 CDD:238012
EGF_Lam 314..>342 CDD:238012
IgI_Tie2 348..439 CDD:409556
Ig strand B 366..370 CDD:409556
Ig strand C 382..386 CDD:409556
Ig strand E 407..411 CDD:409556
Ig strand F 421..426 CDD:409556
Ig strand G 434..437 CDD:409556
fn3 445..520 CDD:394996
fn3 544..626 CDD:394996
FN3 639..731 CDD:238020
PTKc_Tie2 816..1118 CDD:133219 110/280 (39%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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