DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment FER and BTK

DIOPT Version :9

Sequence 1:NP_524288.3 Gene:FER / 41118 FlyBaseID:FBgn0000723 Length:1325 Species:Drosophila melanogaster
Sequence 2:NP_001274273.1 Gene:BTK / 695 HGNCID:1133 Length:693 Species:Homo sapiens


Alignment Length:387 Identity:133/387 - (34%)
Similarity:212/387 - (54%) Gaps:39/387 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly   959 EWFHGVLPREEVVRLL---NNDGDFLVRETIRNEESQIVLSVCWNGH-----KHFIVQTTGEGNF 1015
            ||:...:.|.:..:||   ..:|.|:||::.:..:..:.:.....|.     :|::|.:|.:..:
Human   314 EWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQY 378

  Fly  1016 RF-EGPPFASIQELI-MHQYHSELPVTVKSGAI--LRRPVCRER-------------WELSNDDV 1063
            .. |...|::|.||| .||::|       :|.|  |:.||.::.             ||:...|:
Human   379 YLAEKHLFSTIPELINYHQHNS-------AGLISRLKYPVSQ
QNKNAPSTAGLGYGSWEIDPKDL 436

  Fly  1064 VLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGIC 1128
            ..|:.:|.|.||.|...|.:. :.|||:|..:.....|.  :|::|.:::....|..:|:|.|:|
Human   437 TFLKELGTGQFGVVKYGKWRG-QYDVAIKMIKEGSMSED--EFIEEAKVMMNLSHEKLVQLYGVC 498

  Fly  1129 VQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLV 1193
            .:::||.|:.|.:..|.||.|||:..:...|:|.:.||:|....|.|||||..:|||||||||||
Human   499 TKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLV 563

  Fly  1194 DLEHSVKISDFGMSRE--EEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSK 1256
            :.:..||:||||:||.  ::||..|.|.| .||:|:.||.|.:.|::|..|:|::|:|||||:|.
Human   564 NDQGVVKVSDFGLSRYVLDDEYTSSVGSK-FPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSL 627

  Fly  1257 GDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIY-NVVDAL 1317
            |..||...|||...|.|..|.|:..|....|::|.:|..||...|:.||.|..:. |::|.:
Human   628 GKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVM 689

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FERNP_524288.3 F-BAR_Fes_Fer 7..243 CDD:153341
SH2_Fps_family 953..1039 CDD:198224 22/89 (25%)
TyrKc 1063..1311 CDD:197581 101/249 (41%)
PTKc_Fes_like 1067..1315 CDD:270637 101/250 (40%)
BTKNP_001274273.1 PH 38..167 CDD:278594
PH_Btk 40..200 CDD:269944
SH3_BTK 251..305 CDD:212839
SH2_Tec_Btk 308..413 CDD:198260 27/105 (26%)
PTKc_Btk_Bmx 431..686 CDD:173657 103/258 (40%)
Pkinase_Tyr 436..685 CDD:285015 101/252 (40%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000006
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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