DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and Ddr2

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_113952.2	Gene:	Ddr2 / 685781	RGDID:	619855	Length:	854	Species:	Rattus norvegicus

Alignment Length:	459	Identity:	124/459 - (27%)
Similarity:	199/459 - (43%)	Gaps:	108/459 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   900 PFESSSGELDENSDRDIDNDEEEEDSASDDVLSMKDHCYCVPSLAASISLSTNRPLYEEEWFHGV 964
            |.|||.    .|::......|:|.:|..|.:..:                   ||.|:|.
  Rat   448 PSESSM----FNNNHSSSPSEQESNSTYDRIFPL-------------------RPDYQEP----- 484

  Fly   965 LPREEVVRLLNNDGDFLVRETIRNEE---SQIVLSVCWNGHKHFIVQTTGEGNFRFEGPPFASIQ 1026
                  .||:....:|...|    ||   |.:|.....||         .||...:......::|
  Rat   485 ------SRLIRKLPEFAPGE----EESGCSGVVKPAQPNG---------PEGVPHYAEADIVNLQ 530

  Fly  1027 ELIMHQYHSELPVTVKSGAILRRPVCRERWELSNDDVVL----------LERIGRGNFGDVY--- 1078
            .:.....:|...||:..              ||..||.:          .|::|.|.||:|:
  Rat   531 GVTGGNTYSVPAVTMDL--------------LSGKDVAVEEFPRKLLAFKEKLGEGQFGEVHLCE 581

  Fly  1079 -----KAKLKSTKLD--------VAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQ 1130
                 |.|.|...||        ||||..|.......:..||:|.:|:.:....||::|:.:|:.
  Rat   582 VEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDANIIRLLAVCIT 646

  Fly  1131 KQPIMIVMELVLGGSLLTYLRK-------NSNGLTTRQQMG-MCRDAAAGMRYLESKNCIHRDLA 1187
            :.|:.::.|.:..|.|..:|.:       :||...:...:. |....|:||:||.|.|.:|||||
  Rat   647 EDPLCMITEYMENGDLNQFLSRHEPLSSGSSNATVSYANLKFMATQIASGMKYLSSLNFVHRDLA 711

  Fly  1188 ARNCLVDLEHSVKISDFGMSRE--EEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILM 1250
            .|||||...:::||:||||||.  ..:|....|...:|::|.:.|::..||:|:..|||::|:.:
  Rat   712 TRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTL 776

  Fly  1251 WEIFS-KGDTPYSGMTNSRARERIDTGYR-------MPTPKSTPEEMYRLMLQCWAADAESRPHF 1307
            ||.|: ..:.|||.:::.:..|.....:|       :|.|...|:.:|:|||.||..:.:.||.|
  Rat   777 WETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQIYLPQPAVCPDSVYKLMLSCWRRETKHRPSF 841

  Fly  1308 DEIY 1311
            .||:
  Rat   842 QEIH 845

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	18/88 (20%)
		TyrKc	1063..1311	CDD:197581	91/291 (31%)
		PTKc_Fes_like	1067..1315	CDD:270637	91/279 (33%)
Ddr2	NP_113952.2	FA58C	32..184	CDD:238014
Ddr2	NP_113952.2	PKc_like	557..850	CDD:419665	91/289 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910