Protein Alignment FER and SYK

DIOPT Version :9

• Sequence 1: NP_524288.3
• Gene: FER / 41118
• FlyBaseID: FBgn0000723
• Length: 1325
• Species: Drosophila melanogaster
• Sequence 2: NP_001167638.1
• Gene: SYK / 6850
• HGNCID: 11491
• Length: 635
• Species: Homo sapiens
• Alignment Length: 561
• Identity: 161/561 - (28%)
• Similarity: 232/561 - (41%)
• Gaps: 160/561 - (28%)

  Fly   881 PAGQKPVKPSVQISGHKDHPFESSSGELDENSDRDIDND--EEEEDSASDDVLSMKDHCYCVPSL 943
            |.|.:|          |..|||    :|.||..|:....  ..:..:....::|.|      |.|
Human   110 PQGVQP----------KTGPFE----DLKENLIREYVKQTWNLQGQALEQAIISQK------PQL 154

  Fly   944 AASISLSTNRPLYEEEWFHGVLPREEVVRLL----NNDGDFLVRETIRN--------EESQIV-- 994
            ...|:.:.:..:   .||||.:.|||..:::    ..:|.||:|....|        .|.:::
Human   155 EKLIATTAHEKM---PWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHY 216

  Fly   995 ---------LSV--------CWNGHKHFIVQTTG--------------EGNFRFEGPPFASIQEL 1028
                     ||:        .|...:|:..:..|              :||..|.|.|
Human   217 RIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRP------- 274

  Fly  1029 IMHQYHSELPVTVKSGAILRR-------------------------------------------- 1049
               |.....|.|..:|.|:.|
Human   275 ---QLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGP 336

  Fly  1050 -----PVCRERWELSNDD-------VVLLER---------IGRGNFGDVYKA--KLKSTKLDVAV 1091
                 |:..|.:|....|       .|.|:|         :|.||||.|.|.  ::|.....|||
Human   337 QREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAV 401

  Fly  1092 KTCRMTLPDEQ-KRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSN 1155
            |..:....|.. |.:.|.|..:::|.|:|.||::|||| :.:..|:|||:...|.|..||::|.:
Human   402 KILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGIC-EAESWMLVMEMAELGPLNKYLQQNRH 465

  Fly  1156 GLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMS---REEEEYIVSD 1217
             :..:..:.:....:.||:|||..|.:||||||||.|:..:|..||||||:|   |.:|.|..:.
Human   466 -VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQ 529

  Fly  1218 GMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTP 1282
            ...:.||||.|||.:|:.|::|..||||:|:||||.||.|..||.||..|.....::.|.||..|
Human   530 THGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCP 594

  Fly  1283 KSTPEEMYRLMLQCWAADAESRPHFDEIYNVVDALILRLDN 1323
            ...|.|||.||..||..|.|:||.|       .|:.|||.|
Human   595 AGCPREMYDLMNLCWTYDVENRPGF-------AAVELRLRN 628

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	24/130 (18%)
		TyrKc	1063..1311	CDD:197581	107/262 (41%)
		PTKc_Fes_like	1067..1315	CDD:270637	105/262 (40%)
SYK	NP_001167638.1	SH2_N-SH2_Zap70_Syk_like	13..116	CDD:198191	3/15 (20%)
		Interdomain A	108..167		16/79 (20%)
		SH2_C-SH2_Syk_like	164..262	CDD:198264	18/100 (18%)
		Interdomain B	260..370		18/119 (15%)
		PTKc_Syk	375..631	CDD:133247	109/263 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910