DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and SRMS

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_543013.1	Gene:	SRMS / 6725	HGNCID:	11298	Length:	488	Species:	Homo sapiens

Alignment Length:	401	Identity:	127/401 - (31%)
Similarity:	204/401 - (50%)	Gaps:	54/401 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   947 ISLSTNRPLYEEEWFHGVLPREEVVRLL----NNDGDFLVRETIRNEESQI---------VLSVC 998
            ::.::...|.::.|:...:.|.:..:||    |..|.||:|.:    ||.:         ...||
Human   107 VAKASPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPS----ESSLGGYSLSVRAQAKVC 167

  Fly   999 WNGHKHFIVQTTGEGNFRFE-GPPFASIQELIMHQYHSELPVTVKSGAILRRPV---C------- 1052
                 |:.|....:|:...: |..|..::||:.: |.:       :..:::.|:   |
Human   168 -----HYRVSMAADGSLYLQKGRLFPGLEELLTY-YKA-------NWKLIQNPLLQPCMPQKAPR 219

  Fly  1053 RERWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVA---VKTCRMTLPDEQKRKFLQEGRILK 1114
            ::.||..:.:..|..::|.|.||:|::. |....|.||   :|:..|.|.|..|     |.:.||
Human   220 QDVWERPHSEFALGRKLGEGYFGEVWEG-LWLGSLPVAIKVIKSANMKLTDLAK-----EIQTLK 278

  Fly  1115 QYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYL-RKNSNGLTTRQQMGMCRDAAAGMRYLES 1178
            ...|..:::|..:|...:|:.||.||:..|:|..:| ......|.....:|.....|.||.|||.
Human   279 GLRHERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLEE 343

  Fly  1179 KNCIHRDLAARNCLVDLEHSVKISDFGMSR--EEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLC 1241
            :..:||||||||.|||...:.|::|||::|  :::.|..|...| ||||||||||.|:..::...
Human   344 QRVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSK-IPVKWTAPEAANYRVFSQKS 407

  Fly  1242 DVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPH 1306
            ||||:|:|:.|:|:.|..||.||||....::|..|||:|.|.:.|.|:|.|||:||.:..|.||.
Human   408 DVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLECWRSSPEERPS 472

  Fly  1307 FDEIYNVVDAL 1317
            |..:...:.|:
Human   473 FATLREKLHAI 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	22/99 (22%)
		TyrKc	1063..1311	CDD:197581	100/253 (40%)
		PTKc_Fes_like	1067..1315	CDD:270637	99/253 (39%)
SRMS	NP_543013.1	SH3_Srms	55..109	CDD:212780	0/1 (0%)
		SH2	119..197	CDD:301589	20/87 (23%)
		PTKc_Srm_Brk	223..483	CDD:133248	102/266 (38%)
		STYKc	232..480	CDD:214568	100/254 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910