Protein Alignment FER and SRC

DIOPT Version :9

• Sequence 1: NP_524288.3
• Gene: FER / 41118
• FlyBaseID: FBgn0000723
• Length: 1325
• Species: Drosophila melanogaster
• Sequence 2: XP_016883513.1
• Gene: SRC / 6714
• HGNCID: 11283
• Length: 542
• Species: Homo sapiens
• Alignment Length: 550
• Identity: 171/550 - (31%)
• Similarity: 254/550 - (46%)
• Gaps: 112/550 - (20%)

  Fly   836 RSKPCKQCTKRRRIHPSKSVFDFAKEFEVEQPAGSAADEQFCNCPPAGQKPVKPSVQISGHKD-- 898
            :|||.....:||.:.|:::|          ..||..|.       ||.|.|.||: ...||:.
Human     5 KSKPKDASQRRRSLEPAENV----------HGAGGGAF-------PASQTPSKPA-SADGHRGPS 51

  Fly   899 --------HP-----FESS--------SGEL-------------DENSDRDID----------ND 919
                    .|     |.||        :|.|             :..::.|:.          |:
Human    52 AAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNN 116

  Fly   920 EEEEDSASDD-----VLSMKDHCYCVPS--LAASISLSTNRPLYEEEWFHGVLPREEVVRLL--- 974
            ..:.|....|     .||.....| :||  :|.|.|:..      |||:.|.:.|.|..|||
Human   117 TRKVDVREGDWWLAHSLSTGQTGY-IPSNYVAPSDSIQA------EEWYFGKITRRESERLLLNA 174

  Fly   975 -NNDGDFLVRETIRNEESQIVLSVCWNGH------KHFIVQTTGEGNFRFEG-PPFASIQELIMH 1031
             |..|.|||||: ...:....|||....:      ||:.::....|.|.... ..|.|:|:|:
Human   175 ENPRGTFLVRES-ETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLV-- 236

  Fly  1032 QYHSE--------LPVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLD 1088
            .|:|:        |.....:.....:.:.::.||:..:.:.|..::|:|.||:|:......| ..
Human   237 AYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGT-TR 300

  Fly  1089 VAVKTCRM-TLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRK 1152
            ||:||.:. |:..|   .||||.:::|:..|..:|:|..: |.::||.||.|.:..||||.:| |
Human   301 VAIKTLKPGTMSPE---AFLQEAQVMKKLRHEKLVQLYAV-VSEEPIYIVTEYMSKGSLLDFL-K 360

  Fly  1153 NSNG--LTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSR--EEEEY 1213
            ...|  |...|.:.|....|:||.|:|..|.:||||.|.|.||......|::|||::|  |:.||
Human   361 GETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEY 425

  Fly  1214 IVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYR 1278
            ....|.| .|:|||||||..:|::|...||||:|||:.|:.:||..||.||.|....::::.|||
Human   426 TARQGAK-FPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYR 489

  Fly  1279 MPTPKSTPEEMYRLMLQCWAADAESRPHFD 1308
            ||.|...||.::.||.|||..:.|.||.|:
Human   490 MPCPPECPESLHDLMCQCWRKEPEERPTFE 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	30/104 (29%)
		TyrKc	1063..1311	CDD:197581	103/250 (41%)
		PTKc_Fes_like	1067..1315	CDD:270637	102/246 (41%)
SRC	XP_016883513.1	SH3_Src	88..149	CDD:212941	10/61 (16%)
		SH2_Src_Src	153..253	CDD:198228	30/108 (28%)
		PTKc_Src	266..542	CDD:270656	105/260 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910