DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and epha4a

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_005171372.1	Gene:	epha4a / 64271	ZFINID:	ZDB-GENE-001207-7	Length:	1034	Species:	Danio rerio

Alignment Length:	757	Identity:	193/757 - (25%)
Similarity:	299/757 - (39%)	Gaps:	204/757 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   665 RKLAKDPD-------SQTKRSSSSSSECRSSKDTSHSKKRSLSFSQ--KSISNIFSNLKEFS--- 717
            |.||.|..       |.:.|..|:|..|......|.:...|:..:|  .:..::.||:.|.|
Zfish   285 RALATDGSCSKCPLHSYSVREGSTSCACDKGFFRSETDPASMPCTQPPSAPQHLISNVNETSVNL 349

  Fly   718 --KSPLVRMGKNHILNE------EQDAKRTQPSQHH-HSSGSDCPTNSSSSSSNNNNNNKNTS-- 771
              .:|....|:..:...      ..|.:|.||..:. |.|.......::..|.|:...:.|.:
Zfish   350 EWTAPASSGGRQDLAYNVICKRCSSDGQRCQPCGNGIHFSPQQLGLRTTRVSINDLQAHTNYTFE 414

  Fly   772 -------SNSNHSASQSTIITSTITTTITTTTTTTPSKENSR-----------------LKFKVP 812
                   |..:....|:..:|.|......:..||..:|:.:|                 |:::|.
Zfish   415 IWAVNGVSKQSPGPEQAVSVTVTTNQAAPSPVTTIQAKDITRHAVSLAWQQPERPNGVILEYEVK 479

  Fly   813 KIQKKS-----KAIRNTFRSKLLNFQLKRSKPCKQCTKRRRIHPSKSVFDFAKEFE-----VEQP 867
            ..:|..     :.::.:.||.    ::|...|........|...:....:|:..||     |..|
Zfish   480 YYEKDQNERSYRIMKTSSRSA----EIKGLSPLTSYVFHVRARTAAGYGEFSAPFEFMTNSVPSP 540

  Fly   868 -AGSAADEQ---------------FCNCPPAGQKPVKPSVQIS-GHKD------HPFESSSGELD 909
             .|..|:..               |.......::.|.||...| |.:.      :||...|....
Zfish   541 IIGDGANSTVLLVSVIGSVILLLIFIGVFIISRRQVTPSSAGSLGLRQCPLWCCYPFHCFSSVTC 605

  Fly   910 ENSDRDIDNDEEEEDSASDDVLSMKDHCYCVPSLAASISLSTNRPLYEEEWFHGVLPREEVVRLL 974
            .:::|.....:.::||..:..|......|..|
Zfish   606 PHTERRSKYSKAKQDSDEERHLHPGVRIYVDP--------------------------------- 637

  Fly   975 NNDGDFLVRETIRNEESQIVLSVCWNGHKHFIVQTTGEGNFRFEGPPFASIQELIMHQYHSELPV 1039
                                                    |.:|.|..|      :.::..|:..
Zfish   638 ----------------------------------------FTYEDPNQA------VREFAKEIDA 656

  Fly  1040 TVKSGAILRRPVCRERWELSNDDVVLLER-IGRGNFGDVYKAKLK---STKLDVAVKTCRMTLPD 1100
            :           |           :.:|: ||.|.||:|...:||   ..::.||:||.:....|
Zfish   657 S-----------C-----------IKIEKVIGIGEFGEVCSGRLKMPGKREICVAIKTLKAGYTD 699

  Fly  1101 EQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGM 1165
            :|:|.||.|..|:.|:|||||::|.|:..:.:|:||:.|.:..|||..:||||....|..|.:|:
Zfish   700 KQRRDFLSEASIMGQFDHPNIIRLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGI 764

  Fly  1166 CRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSREEEE-----YIV--------SD 1217
            .|..|:||:||...:.:||||||||.||:.....|:|||||||..||     |..        |.
Zfish   765 LRGIASGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEEDPDAAYTTREITGTYQSQ 829

  Fly  1218 GMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTP 1282
            |.| ||::||||||:.:.|:||..|||||||:|||:.|.|:.||..|:|....:.|:.|||:|.|
Zfish   830 GGK-IPIRWTAPEAITYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPP 893

  Fly  1283 KSTPEEMYRLMLQCWAADAESRPHFDEIYNVVDALILRLDNS 1324
            ...|..:::|||.||..:...||.|.:|.|::|.|| |..||
Zfish   894 MDCPVSLHQLMLDCWQKERAERPKFSQIVNMLDKLI-RNPNS 934

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	5/85 (6%)
		TyrKc	1063..1311	CDD:197581	114/264 (43%)
		PTKc_Fes_like	1067..1315	CDD:270637	116/264 (44%)
epha4a	XP_005171372.1	EphR_LBD_A4	33..206	CDD:198450
		FN3	332..438	CDD:238020	18/105 (17%)
		FN3	443..534	CDD:238020	15/94 (16%)
		EphA2_TM	554..654	CDD:291255	19/178 (11%)
		PTKc_EphR_A	654..929	CDD:270651	118/297 (40%)
		Pkinase_Tyr	659..925	CDD:285015	116/266 (44%)
		SAM_EPH-A4	959..1029	CDD:188944
		SAM	960..1023	CDD:197735
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910