DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and Epha8

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_038967225.1	Gene:	Epha8 / 60589	RGDID:	708543	Length:	1004	Species:	Rattus norvegicus

Alignment Length:	409	Identity:	133/409 - (32%)
Similarity:	197/409 - (48%)	Gaps:	68/409 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   942 SLAASISLSTNRPLYEEE---WFHGVLPREEVVRLLNNDGDFLVRETIRNEESQIVLSVCWNGH- 1002
            |.|..:.....||.|:..   |....|....||.||                    |.:|...|
  Rat   523 SQAMEVETGKPRPRYDTRTIVWICLTLITGLVVLLL--------------------LLICKKRHC 567

  Fly  1003 ---KHFIVQTTGEGNFRFEG----PPFASIQELIMHQYHSELPVTV------------KSGAILR 1048
               |.|  |.:.|....::.    ||..    |.::....:||.|.            ::|....
  Rat   568 GYSKAF--QDSDEEKMHYQNGQAPPPVF----LPLNHPPGKLPETQFSAEPHNYEEPGRAGRSFT 626

  Fly  1049 RPVCRERWELSNDDVVLLER-IGRGNFGDVYKAKLK---STKLDVAVKTCRMTLPDEQKRKFLQE 1109
            |.:...|        :.:|: ||.|..|:|...:|:   ...:.||:|..:....:.|::.||:|
  Rat   627 REIEASR--------IHIEKIIGSGESGEVCYGRLQVPGQRDVPVAIKALKAGYTERQRQDFLRE 683

  Fly  1110 GRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMR 1174
            ..|:.|:|||||::|.|:..:.:..|||.|.:..|||..:||.:....|..|.:||.:...||||
  Rat   684 AAIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDAFLRTHDGQFTILQLVGMLKGVGAGMR 748

  Fly  1175 YLESKNCIHRDLAARNCLVDLEHSVKISDFGMSREEEE-----YIVSDGMKQIPVKWTAPEALNF 1234
            ||.....|||||||||.|||.....|:||||:||..|:     |..:.|  :||::||||||:.|
  Rat   749 YLSDLGYIHRDLAARNILVDGRLVCKVSDFGLSRALEDDPEAAYTTAGG--KIPIRWTAPEAIAF 811

  Fly  1235 GKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAA 1299
            ..::|..||||:|::|||:.:.|:.||..|||......::.|||:|.|...|..:::|||.||..
  Rat   812 RTFSSASDVWSFGVVMWEVLAYGERPYWNMTNQDVISSVEEGYRLPAPMGCPRALHQLMLDCWHK 876

  Fly  1300 DAESRPHFDEIYNVVDALI 1318
            |...||.|..:.:|::||:
  Rat   877 DRAQRPRFSHVVSVLEALV 895

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	20/96 (21%)
		TyrKc	1063..1311	CDD:197581	103/256 (40%)
		PTKc_Fes_like	1067..1315	CDD:270637	104/256 (41%)
Epha8	XP_038967225.1	EphR_LBD	30..202	CDD:413445
		fn3	329..422	CDD:394996
		FN3	439..530	CDD:238020	2/6 (33%)
		PKc_like	629..895	CDD:419665	106/275 (39%)
		SAM_EPH-A8	932..994	CDD:188949
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910