DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and Matk

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_038935769.1	Gene:	Matk / 60450	RGDID:	69058	Length:	496	Species:	Rattus norvegicus

Alignment Length:	422	Identity:	136/422 - (32%)
Similarity:	198/422 - (46%)	Gaps:	86/422 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   948 SLSTNRPLYEEEWFHGVLPREEVVRLLN--NDGDFLVRETIRNEESQIVLSVCWNG--------H 1002
            :|||:..|....||||.:..:|.::.|.  .||.|||||:.|: ....||.|.:..        |
  Rat    69 ALSTDPKLSLMPWFHGKISGQEAIQQLQPPEDGLFLVRESARH-PGDYVLCVSFGRDVIHYRVLH 132

  Fly  1003 K--HFIVQTTGEGNFRFEGPPFASIQELIMHQYHSELPVTVKSGAILRRPVCRER---------- 1055
            :  |..:.         |...|.::.:::.|       .|...|||..:.|..:|
  Rat   133 RDGHLTID---------EAVCFCNLMDMVEH-------YTRDKGAICTKLVKPKRKQGAKSAEEE 181

  Fly  1056 -----WELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQ 1115
                 |.|....:.|..:||.|.||.|.:.:....|  ||||..:.   |...:.||.|..::.:
  Rat   182 LAKAGWLLDLQHLTLGAQIGEGEFGAVLQGEYLGQK--VAVKNIKC---DVTAQAFLDETAVMTK 241

  Fly  1116 YDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGL-TTRQQMGMCRDAAAGMRYLESK 1179
            ..|.|:|:|:|: :....:.||||.|..|:|:.:||.....| :|.|.:......|.||.|||||
  Rat   242 LQHRNLVRLLGV-ILHHGLYIVMEHVSKGNLVNFLRTRGRALVSTSQLLQFALHVAEGMEYLESK 305

  Fly  1180 NCIHRDLAARNCLVDLEHSVKISDFGMSREEEEYIVSDGM--KQIPVKWTAPEALNFGKYTSLCD 1242
            ..:||||||||.||..:...|:||||:::.|    :..|:  .::||||||||||..|:::|..|
  Rat   306 KLVHRDLAARNILVSEDLVAKVSDFGLAKAE----LRKGLDSSRLPVKWTAPEALKNGRFSSKSD 366

  Fly  1243 VWSYGILMWEIFSKGDTPYSGMTNS-----------------------------RARERIDTGYR 1278
            |||:|:|:||:||.|..||..|.:|                             ...|.::.|||
  Rat   367 VWSFGVLLWEVFSYGRAPYPKMVSSTPGRAACASRVTDCPHPCYPLPPYLQSLKEVSEAVEKGYR 431

  Fly  1279 MPTPKSTPEEMYRLMLQCWAADAESRPHFDEI 1310
            |..|.|.|..::.||..||.|:...||.|.:|
  Rat   432 MEPPDSCPGPVHTLMGSCWEAEPSRRPPFRKI 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	23/97 (24%)
		TyrKc	1063..1311	CDD:197581	102/280 (36%)
		PTKc_Fes_like	1067..1315	CDD:270637	101/276 (37%)
Matk	XP_038935769.1	SH3	9..67	CDD:418401
		SH2_csk_like	77..174	CDD:198190	28/113 (25%)
		PKc_like	187..470	CDD:419665	104/287 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810