DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and RET

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_066124.1	Gene:	RET / 5979	HGNCID:	9967	Length:	1114	Species:	Homo sapiens

Alignment Length:	1003	Identity:	240/1003 - (23%)
Similarity:	379/1003 - (37%)	Gaps:	276/1003 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   457 HFKRKSTPQPATPMTRSRQGRFNKLQPRSQSLGSLSVIRDGNGPSPARYEPITNHRLRQAASVHY 521
            :|...:|..||....:.|:..|.:.:|..:       ||:...|.       |.|:.| ...|.:
Human   146 YFSFFNTSFPACSSLKPRELCFPETRPSFR-------IRENRPPG-------TFHQFR-LLPVQF 195

  Fly   522 LGEEIATS----------STNPPD---------LTRLRRTQCSMLCL-----GEDEEPVVLASPA 562
            |...|:.:          ....||         |.|.:|.:..::.:     |..||.|::  |.
Human   196 LCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMV--PF 258

  Fly   563 PLT---------QLTAAVLTNTNNNHIYADLELDKKKDTSPSPECKGEQIQPKKEQIRIEINQTA 618
            |:|         ...|.|.|.:      |.:|..:|:||..:             .:|:......
Human   259 PVTVYDEDDSAPTFPAGVDTAS------AVVEFKRKEDTVVA-------------TLRVFDADVV 304

  Fly   619 PQNSIDAHLDRIDELNRVLDDRLKRTLQPSDDVNAIESAEENHIQTRKLAKDPDSQTKRSSSSSS 683
            |.:.         ||.|    |...||.|.|....         ||.::...|:..:.:::.|
Human   305 PASG---------ELVR----RYTSTLLPGDTWAQ---------QTFRVEHWPNETSVQANGS-- 345

  Fly   684 ECRSSKDTSHSKK----RSLSFSQKSISNI--------FSN------LKEFSKSPL---VRMGKN 727
               ..:.|.|..:    |:||.|:.....:        |..      |..|:.|.|   :.:...
Human   346 ---FVRATVHDYRLVLNRNLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPST 407

  Fly   728 HILNEEQDAKRTQPSQHHHSSGSDCPTNSSSSSSNNNNNNKNTSSNSNHSASQSTIITSTITTT- 791
            :.|:..:.|:|      ....|..|..| ..:.|..|...|..||.:|  .|...::||...|:
Human   408 YSLSVSRRARR------FAQIGKVCVEN-CQAFSGINVQYKLHSSGAN--CSTLGVVTSAEDTSG 463

  Fly   792 --ITTTTTTTPSKENSRLKFKVPKIQKKSK---------AIRNTFRSKLLNFQL-----KRSKPC 840
              ....|......:.:.|.:.|....:::.         .:..::.::.....|     ||...|
Human   464 ILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLEC 528

  Fly   841 KQC------TKR--RRIHPSKSVFDFAKEFEVEQPAGSAADEQFCN---------CPPAGQKPVK 888
            ::|      |.|  .|....|.:   .:.|....|:.....:..|:         ||   |..::
Human   529 EECGGLGSPTGRCEWRQGDGKGI---TRNFSTCSPSTKTCPDGHCDVVETQDINICP---QDCLR 587

  Fly   889 PSVQISGHKDHPFESSSGELDENSDRDID------NDEEEEDSASDDVLSMKDHCYCVPSLAASI 947
            .|: :.||:       .||     .|.|.      |...||:.           |:|.|.
Human   588 GSI-VGGHE-------PGE-----PRGIKAGYGTCNCFPEEEK-----------CFCEPE----- 623

  Fly   948 SLSTNRPLYEEEWFHGVLPREEVVRLLNNDGDFLVRETIRNEESQIVLSV----CWNGHKHFIVQ 1008
              ....||.:|      |.|..:...:.  ..|:|         .::||.    |::...|....
Human   624 --DIQDPLCDE------LCRTVIAAAVL--FSFIV---------SVLLSAFCIHCYHKFAHKPPI 669

  Fly  1009 TTGEGNFRFEGPPFASIQELIMHQYHS-----------ELPVTVKSGAILRRPVCRERWELSNDD 1062
            ::.|..||.....|..       .|.|           |..|:|.:..||..|    :||....:
Human   670 SSAEMTFRRPAQAFPV-------SYSSSGARRPSLDSMENQVSVDAFKILEDP----KWEFPRKN 723

  Fly  1063 VVLLERIGRGNFGDVYKA-----KLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIV 1122
            :||.:.:|.|.||.|.||     |.::....||||..:......:.|..|.|..:|||.:||:::
Human   724 LVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVI 788

  Fly  1123 KLIGICVQKQPIMIVMELVLGGSLLTYLR---------------KNSN--------GLTTRQQMG 1164
            ||.|.|.|..|:::::|....|||..:||               :||:        .||....:.
Human   789 KLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLIS 853

  Fly  1165 MCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSRE--EEEYIVSDGMKQIPVKWT 1227
            .....:.||:||.....:||||||||.||.....:||||||:||:  ||:..|.....:|||||.
Human   854 FAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWM 918

  Fly  1228 APEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRL 1292
            |.|:|....||:..||||:|:|:|||.:.|..||.|:...|....:.||:||..|.:..||||||
Human   919 AIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRL 983

  Fly  1293 MLQCWAADAESRPHFDEIYNVVDALILR 1320
            |||||..:.:.||.|.:|...::.::::
Human   984 MLQCWKQEPDKRPVFADISKDLEKMMVK 1011

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	18/100 (18%)
		TyrKc	1063..1311	CDD:197581	106/277 (38%)
		PTKc_Fes_like	1067..1315	CDD:270637	105/277 (38%)
RET	NP_066124.1	Cadherin	172..261	CDD:278457	21/105 (20%)
		PTKc_RET	723..1012	CDD:173631	107/289 (37%)
		Pkinase_Tyr	724..1005	CDD:285015	107/280 (38%)
		Inhibitors binding	805..807		1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910