DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and Erbb4

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_067719.2	Gene:	Erbb4 / 59323	RGDID:	620486	Length:	1308	Species:	Rattus norvegicus

Alignment Length:	261	Identity:	92/261 - (35%)
Similarity:	154/261 - (59%)	Gaps:	11/261 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly  1058 LSNDDVVLLERIGRGNFGDVYKA----KLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDH 1118
            |...::..::.:|.|.||.|||.    :.::.|:.||:|....|...:...:|:.|..|:...||
  Rat   713 LKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASVDH 777

  Fly  1119 PNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKNCIH 1183
            |::|:|:|:|: ...|.:|.:|:..|.||.|:.::.:.:.::..:..|...|.||.|||.:..:|
  Rat   778 PHLVRLLGVCL-SPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVH 841

  Fly  1184 RDLAARNCLVDLEHSVKISDFGMSR----EEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVW 1244
            |||||||.||...:.|||:|||::|    :|:||....|  ::|:||.|.|.:::.|:|...|||
  Rat   842 RDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGG--KMPIKWMALECIHYRKFTHQSDVW 904

  Fly  1245 SYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDE 1309
            |||:.:||:.:.|..||.|:......:.::.|.|:|.|.....::|.:|::||..||:|||.|.|
  Rat   905 SYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKE 969

  Fly  1310 I 1310
            :
  Rat   970 L 970

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224
		TyrKc	1063..1311	CDD:197581	91/256 (36%)
		PTKc_Fes_like	1067..1315	CDD:270637	91/252 (36%)
Erbb4	NP_067719.2	Recep_L_domain	55..167	CDD:395817
		Furin-like	186..332	CDD:395614
		Recep_L_domain	358..478	CDD:395817
		GF_recep_IV	502..634	CDD:405525
		TM_ErbB4	642..685	CDD:213053
		Nuclear localization signal. /evidence=ECO:0000250	676..684
		PTKc_HER4	710..1012	CDD:173655	92/261 (35%)
		PPxy motif 1	1032..1035
		PPxY motif 2	1298..1301
		PDZ-binding	1306..1308
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910