DRSC/TRiP Functional Genomics Resources

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Protein Alignment FER and Ntrk1

DIOPT Version :9

Sequence 1:NP_524288.3 Gene:FER / 41118 FlyBaseID:FBgn0000723 Length:1325 Species:Drosophila melanogaster
Sequence 2:NP_067600.1 Gene:Ntrk1 / 59109 RGDID:620144 Length:799 Species:Rattus norvegicus


Alignment Length:473 Identity:128/473 - (27%)
Similarity:213/473 - (45%) Gaps:90/473 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   881 PAGQKPVKPSVQISGHKDHPFESSSGELDENSDRDIDNDEEEEDSASDDVLSMKDHCYCVPSLAA 945
            |.||  ...|: ::...|:|||.:..:....|...:|.     :|.|.|.:..||......|:|.
  Rat   369 PYGQ--AAASI-MAAFMDNPFEFNPEDPIPVSFSPVDT-----NSTSRDPVEKKDETPFGVSVAV 425

  Fly   946 SISLSTNRPLYEEEWFHGVLPREEVVRLLNNDGD----FLVRETIRNEESQIVLSVCWNGHKHFI 1006
            .:::|            ..|....::.:||..|.    .:.|..:...|..:.:|:      ||:
  Rat   426 GLAVS------------AALFLSALLLVLNKCGQRSKFGINRPAVLAPEDGLAMSL------HFM 472

  Fly  1007 V-------QTTGEGNFRFEGPPFASIQELIMH--QYHSELPVTVKSGAILRRPVCRERWELSNDD 1062
            .       .|.|:|         :.:|..||.  ||.|:..|                ..:...|
  Rat   473 TLGGSSLSPTEGKG---------SGLQGHIMENPQYFSDTCV----------------HHIKRQD 512

  Fly  1063 VVLLERIGRGNFGDVYKAKL-----KSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIV 1122
            ::|...:|.|.||.|:.|:.     ...|:.||||..:.| .:..::.|.:|..:|....|.:||
  Rat   513 IILKWELGEGAFGKVFLAECYNLLNDQDKMLVAVKALKET-SENARQDFHREAELLTMLQHQHIV 576

  Fly  1123 KLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNG----------------LTTRQQMGMCRDAAA 1171
            :..|:|.:..|:::|.|.:..|.|..:||  |:|                |...|.:.:....||
  Rat   577 RFFGVCTEGGPLLMVFEYMRHGDLNRFLR--SHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAA 639

  Fly  1172 GMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSRE--EEEYIVSDGMKQIPVKWTAPEALNF 1234
            ||.||.|.:.:|||||.|||||.....|||.||||||:  ..:|....|...:|::|..||::.:
  Rat   640 GMVYLASLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILY 704

  Fly  1235 GKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAA 1299
            .|:::..||||:|:::||||:.|..|:..::|:.|.|.|..|..:..|::.|.::|.:|..||..
  Rat   705 RKFSTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIECITQGRELERPRACPPDVYAIMRGCWQR 769

  Fly  1300 DAESRPHFDEIYNVVDAL 1317
            :.:.|....:::..:.||
  Rat   770 EPQQRLSMKDVHARLQAL 787

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FERNP_524288.3 F-BAR_Fes_Fer 7..243 CDD:153341
SH2_Fps_family 953..1039 CDD:198224 18/98 (18%)
TyrKc 1063..1311 CDD:197581 88/270 (33%)
PTKc_Fes_like 1067..1315 CDD:270637 87/270 (32%)
Ntrk1NP_067600.1 leucine-rich repeat 68..92 CDD:275378
LRR 1 90..113
LRR_8 92..150 CDD:290566
leucine-rich repeat 93..116 CDD:275378
LRR 2 116..137
leucine-rich repeat 117..139 CDD:275378
leucine-rich repeat 140..152 CDD:275378
TPKR_C2 151..194 CDD:293525
I-set 196..284 CDD:254352
Ig_TrkABC_d4 197..284 CDD:143173
Ig_TrKABC_d5 301..382 CDD:143172 4/15 (27%)
Interaction with SQSTM1 472..493 4/29 (14%)
PKc_like 507..786 CDD:304357 89/281 (32%)
STYKc 513..784 CDD:214568 88/273 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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