DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and PTK2

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_024302967.1	Gene:	PTK2 / 5747	HGNCID:	9611	Length:	1119	Species:	Homo sapiens

Alignment Length:	261	Identity:	106/261 - (40%)
Similarity:	154/261 - (59%)	Gaps:	9/261 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly  1056 WELSNDDVVLLERIGRGNFGDVYKAKLKSTK---LDVAVKTCRMTLPDEQKRKFLQEGRILKQYD 1117
            :|:..:.:.|...||.|.||||::....|.:   |.||:|||:....|..:.|||||...::|:|
Human   479 YEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFD 543

  Fly  1118 HPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKNCI 1182
            ||:||||||: :.:.|:.|:|||...|.|.::|:.....|.....:......:..:.|||||..:
Human   544 HPHIVKLIGV-ITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFV 607

  Fly  1183 HRDLAARNCLVDLEHSVKISDFGMSREEEE---YIVSDGMKQIPVKWTAPEALNFGKYTSLCDVW 1244
            |||:||||.||.....||:.|||:||..|:   |..|.|  ::|:||.|||::||.::||..|||
Human   608 HRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKG--KLPIKWMAPESINFRRFTSASDVW 670

  Fly  1245 SYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDE 1309
            .:|:.||||...|..|:.|:.|:....||:.|.|:|.|.:.|..:|.||.:|||.|...||.|.|
Human   671 MFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTE 735

  Fly  1310 I 1310
            :
Human   736 L 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224
		TyrKc	1063..1311	CDD:197581	105/254 (41%)
		PTKc_Fes_like	1067..1315	CDD:270637	104/250 (42%)
PTK2	XP_024302967.1	B41	87..309	CDD:214604
		FERM_C_FAK1	305..415	CDD:270011
		PTKc_FAK	479..748	CDD:133187	106/261 (41%)
		Focal_AT	983..1112	CDD:308942
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910