DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and fynb

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001025140.1	Gene:	fynb / 574422	ZFINID:	ZDB-GENE-050706-89	Length:	544	Species:	Danio rerio

Alignment Length:	386	Identity:	137/386 - (35%)
Similarity:	206/386 - (53%)	Gaps:	53/386 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   958 EEWFHGVLPREEVVRLL----NNDGDFLVRETIRNEESQIVLSV-CWN----GH-KHFIVQTTGE 1012
            |:|:.|.|.|::..|.|    |..|.||:||: ...:....||: .|:    .| ||:.::....
Zfish   154 EDWYFGKLGRKDAERQLLSTGNPRGTFLIRES-ETTKGAFSLSIRDWDDVKGDHVKHYKIRKLDS 217

  Fly  1013 GNFRF-EGPPFASIQELIMH--------------QYHSELP----VTVKSGAILRRPVCRERWEL 1058
            |.:.. ....|.::|:|:.|              ..|..:|    ::||:         ::.||:
Zfish   218 GGYYITTRAQFETLQQLVQHYTERAAGLCCRLVVPCHKGMPRLTDLSVKT---------KDVWEI 273

  Fly  1059 SNDDVVLLERIGRGNFGDVYKAKLK-STKLDVAVKTCRM-TLPDEQKRKFLQEGRILKQYDHPNI 1121
            ..:.:.|::|:|.|.||:|:..... :||  ||:||.:. |:..|   .||:|.:|:|:..|..:
Zfish   274 PRESLQLIKRLGNGQFGEVWMGTWNGNTK--VAIKTLKPGTMSPE---SFLEEAQIMKKLRHDKL 333

  Fly  1122 VKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNG--LTTRQQMGMCRDAAAGMRYLESKNCIHR 1184
            |:|..: |.::||.||.|.:..||||.:| |:..|  |.....:.|....|.||.|:|..|.|||
Zfish   334 VQLYAV-VSEEPIYIVTEYMGKGSLLDFL-KDGEGRALKLPNLVDMAAQVAGGMAYIERMNYIHR 396

  Fly  1185 DLAARNCLVDLEHSVKISDFGMSR--EEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYG 1247
            ||.:.|.||......||:|||::|  |:.||....|.| .|:|||||||..:||:|...||||:|
Zfish   397 DLRSANILVGDSLVCKIADFGLARLIEDNEYTARQGAK-FPIKWTAPEAALYGKFTIKSDVWSFG 460

  Fly  1248 ILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFD 1308
            ||:.|:.:||..||.||.|....|:::.||||..|:..|..::.||:|||..|||.||.|:
Zfish   461 ILLTELVTKGRVPYPGMNNREVLEQVERGYRMQCPQDCPSSLHELMVQCWKKDAEERPTFE 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	26/109 (24%)
		TyrKc	1063..1311	CDD:197581	107/252 (42%)
		PTKc_Fes_like	1067..1315	CDD:270637	106/248 (43%)
fynb	NP_001025140.1	SH3_Fyn_Yrk	92..147	CDD:212939
		SH2_Src_Fyn_isoform_a_like	152..252	CDD:198281	24/98 (24%)
		PKc_like	268..541	CDD:304357	109/262 (42%)
		Pkinase_Tyr	278..527	CDD:285015	107/252 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910