DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and tec

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001108215.1	Gene:	tec / 571588	ZFINID:	ZDB-GENE-030131-7499	Length:	622	Species:	Danio rerio

Alignment Length:	580	Identity:	147/580 - (25%)
Similarity:	247/580 - (42%)	Gaps:	131/580 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   792 ITTTTTTTPSK---------ENSRLKFKVPKIQKKSKAIRNTFRSKLLNFQLKRSKPCKQ----- 842
            :...||..|.:         ::|.|....|..:.:|..::| .:.::.|..|...|...|
Zfish    65 VKNNTTVIPCQNKYPFQVVYDSSTLYIFAPSNESRSVWVQN-IKEEIRNNPLIADKYHSQFWQEG 128

  Fly   843 ----CTKRRRIHPSKSVFDFAKEFEVEQPAGSAADEQFCNCPPAGQKPVKPSVQISGHKDHPFES 903
                |.:..::.|....::...:.. .:|.....::|..:|  .|::|..|.         |.|:
Zfish   129 EWLCCGQVDKLAPGCEGYNLFGDVS-RKPLPPVPEDQNISC--TGRRPPPPP---------PGET 181

  Fly   904 SSGELDENSDRDIDNDEEEEDSASDDVLSMKDHCYCVPSLAASISLSTNRPLY-----EEEWF-- 961
            .               :|||:...:.|:::.|.....|.   .::|.|.....     |..|:
Zfish   182 K---------------QEEEEPEEEVVIALYDFEGLEPH---DLTLKTGEEYVILEKCEVNWYKA 228

  Fly   962 ------HGVLP--------------------------REEVVRLLNNDGDFLVRETIRNEESQIV 994
                  .|.:|                          .||::|....:|.|:||  :.:......
Zfish   229 RNKEGKQGYIPSNYVTEKASDKLEQFIWFSKNVNRNKAEELLRKEGKEGGFMVR--LSSNTGTYT 291

  Fly   995 LSVCWNGH-------KHFIVQTTGEGNFRF---EGPPFASIQELIMHQYHS-------------- 1035
            :|:.....       :|:.::.......:|   |...|.||.|||.:..|:
Zfish   292 VSLYTKSTSDGAAAIRHYQIKEIHASPKQFYLAEKYIFTSIPELIEYHKHNAAGLVSRLRHAVGD 356

  Fly  1036 ---ELPVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRMT 1097
               |.|.|.        ....::||::..::..::.:|.|.||.|...|.:: :..||:||.|..
Zfish   357 QKREAPTTA--------GFSYDKWEINPSELTFMKELGSGQFGVVRLGKWRA-QHKVAIKTIREG 412

  Fly  1098 LPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQ 1162
            ...|.  .|::|.:|:....|.|:|:|.|:|.|::||.:|.|.:..|.||.:||:....|..:..
Zfish   413 AMSED--DFIEEAKIMMNLSHRNLVQLYGVCTQQKPIYLVTEFMELGCLLNFLRQRRGTLAAQDL 475

  Fly  1163 MGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSRE--EEEYIVSDGMKQIPVK 1225
            :|:|.|.:.||::||....||||||||||||:....||:|||||:|.  :::|..|.|.| .|||
Zfish   476 LGICHDISQGMQHLEENRFIHRDLAARNCLVNTSMVVKVSDFGMTRYVLDDQYWSSSGTK-FPVK 539

  Fly  1226 WTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKST 1285
            |:.||..||.:|:|..||||:|:||||:|::|..|:....|......:..|:|:..||.:
Zfish   540 WSPPEVFNFCRYSSKSDVWSFGVLMWEVFTEGKMPFEHSQNHEVVLMVTQGHRLYRPKKS 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	23/151 (15%)
		TyrKc	1063..1311	CDD:197581	90/225 (40%)
		PTKc_Fes_like	1067..1315	CDD:270637	90/221 (41%)
tec	NP_001108215.1	PH	6..111	CDD:278594	8/46 (17%)
		PH_Btk	7..148	CDD:269944	14/83 (17%)
		SH3_Tec	192..246	CDD:212838	9/56 (16%)
		SH2_Tec_Itk	249..356	CDD:198259	18/108 (17%)
		PKc_like	374..602	CDD:304357	90/230 (39%)
		Pkinase_Tyr	379..602	CDD:285015	90/225 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910