Protein Alignment FER and btk

DIOPT Version :9

• Sequence 1: NP_524288.3
• Gene: FER / 41118
• FlyBaseID: FBgn0000723
• Length: 1325
• Species: Drosophila melanogaster
• Sequence 2: XP_021336920.1
• Gene: btk / 568653
• ZFINID: ZDB-GENE-070531-1
• Length: 640
• Species: Danio rerio
• Alignment Length: 561
• Identity: 152/561 - (27%)
• Similarity: 254/561 - (45%)
• Gaps: 107/561 - (19%)

  Fly   845 KRRRIHPSKSVFDFAKEF-------------------EVEQPAGSAADEQFCNC----------- 879
            ::..||..|:|..|.|:.                   ||:|..|       |..
Zfish   100 RKHWIHELKNVVRFNKDLMQKYHPCFWEDGVWKCCLQEVKQAMG-------CRVLETKNGGVFKR 157

  Fly   880 -------------PPAGQKPVKP-----------SVQISGHKDHPFESSSGELDENSDRDIDNDE 920
                         .|..:||.:|           |:.::...::.:...:     .:|.::..||
Zfish   158 GSKNRDSRKPLPPTPEEEKPARPLPPEPPMPPAFSIGMTVIAEYEYAPMT-----TNDLELRKDE 217

  Fly   921 EEE--DSASDDVLSMKDHCYCVPSLAASISLSTNRPLYEEEWFHGVLPREEVVRLL---NNDGDF 980
            |..  :.:..:....||.......:.::..:.....|.:.:|:...:.|.:...||   |.||.|
Zfish   218 EYTLLEISDPNWFKAKDKYGKEGYIPSNYIVQALNGLEKYDWYCKNINRSQAENLLKTENKDGGF 282

  Fly   981 LVRETIRNEESQIVLSV-----------CWNGHKHFIVQTTGEGNFRF-EGPPFASIQELIMHQY 1033
            |||:: .....:..:||           |    :|:.:..|.:|.|.. |...|.:|.|||.:..
Zfish   283 LVRDS-GKFTGKYTVSVFTKAGGETSGSC----RHYNILLTADGQFYLAEKHNFTNIPELINYHQ 342

  Fly  1034 H------SELPVTVKSGAILRRPVCRE-----RWELSNDDVVLLERIGRGNFGDVYKAKLKSTKL 1087
            |      |.|...|.:.|  :...|..     .||:....:..:..:|.|.||.|...|.:. :.
Zfish   343 HNAAGLVSRLKYIVSNRA--QNAPCTAGLGYGSWEIDPRQLTFIRELGNGQFGVVKYGKWQG-RH 404

  Fly  1088 DVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRK 1152
            |||:|..:.....|.  .|::|.:::.:..|.|:|:|.|:|.:::||.||.|.:..|.||.||::
Zfish   405 DVAIKMVKEGSMSED--DFIEEAKVMMKLCHGNLVQLYGVCTKQRPIYIVTEYLANGCLLNYLQE 467

  Fly  1153 NSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSRE--EEEYIV 1215
            .....|:...:.||:|.:.||:|||:...|||||||||||||...::|::|||:||.  ::||..
Zfish   468 GLLNPTSIALLEMCKDVSEGMKYLEANQFIHRDLAARNCLVDSNGTIKVTDFGLSRYVLDDEYTS 532

  Fly  1216 SDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMP 1280
            |.|.| .||:|:.||.|.:.|::|..|:|::|:|||||:::|..||....|:...|:|..|:|:.
Zfish   533 SVGSK-FPVRWSPPEVLLYCKFSSKSDIWAFGVLMWEIYTQGRMPYDRWNNTEIVEKISAGHRLY 596

  Fly  1281 TPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVDALILRL 1321
            .|:...|.::.:|..||....:.||.|.|:..|:..|:..:
Zfish   597 RPQMANENVFAIMNSCWHERPDERPTFQELVGVIKDLLFSM 637

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	28/106 (26%)
		TyrKc	1063..1311	CDD:197581	95/249 (38%)
		PTKc_Fes_like	1067..1315	CDD:270637	96/249 (39%)
btk	XP_021336920.1	PH_Btk	6..145	CDD:269944	10/51 (20%)
		SH3	195..249	CDD:327375	6/58 (10%)
		SH2	252..357	CDD:326550	28/109 (26%)
		PKc_like	376..630	CDD:328722	95/257 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910