DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and fgfr1b

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001155204.1	Gene:	fgfr1b / 567905	ZFINID:	ZDB-GENE-060503-14	Length:	740	Species:	Danio rerio

Alignment Length:	356	Identity:	107/356 - (30%)
Similarity:	168/356 - (47%)	Gaps:	62/356 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly  1027 ELIMHQYHSELPV------------TVKSGAILRRP----------------------VCRERWE 1057
            :|.:|:....:|:            ::.||.:|.||                      .|   ||
Zfish   330 QLAVHKLAKSIPLRRQITVSVESSSSLNSGVMLVRPSRLSSSGTPMLSGVSEYELPQDPC---WE 391

  Fly  1058 LSNDDVVLLERIGRGNFGDVYKAKLKSTKLD-------VAVKTCRMTLPDEQKRKFLQEGRILKQ 1115
            :|.:.:||.:.:|.|.||.|...:......|       ||||..:....::.....:.|..::|.
Zfish   392 VSRERLVLGKPLGEGCFGQVVMGEAIGLDKDKPNRITKVAVKMLKSDATEKDLSDLISEMEMMKM 456

  Fly  1116 Y-DHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLR-KNSNG--------------LTTRQQMG 1164
            . .|.||:.|:|.|.|..|:.:::|....|:|..||| :..:|              ::.:..:.
Zfish   457 IGKHKNIINLLGACTQDGPLYVIVEFASKGNLREYLRARRPHGMEYCYNPDPLPIESMSIKDLVS 521

  Fly  1165 MCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSREEE--EYIVSDGMKQIPVKWT 1227
            .....|.||.||.||.||||||||||.||..::.:||:|||::|:..  :|.......::||||.
Zfish   522 CAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDVHHIDYYKKTTNGRLPVKWM 586

  Fly  1228 APEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRL 1292
            |||||....||...||||:|:|:||||:.|.:||.|:......:.:..|:||..|.:..:|:|.:
Zfish   587 APEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLREGHRMDKPSACTQELYLM 651

  Fly  1293 MLQCWAADAESRPHFDEIYNVVDALILRLDN 1323
            |..||.|....||.|.::...:|..:..:.|
Zfish   652 MKDCWHAVPTQRPTFKQLVEDLDRTLSLISN 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	2/11 (18%)
		TyrKc	1063..1311	CDD:197581	93/272 (34%)
		PTKc_Fes_like	1067..1315	CDD:270637	91/272 (33%)
fgfr1b	NP_001155204.1	I-set	80..167	CDD:254352
		Ig2_FGFR	83..167	CDD:143265
		IG_like	182..278	CDD:214653
		Ig3_FGFR-2	190..278	CDD:143266
		PKc_like	383..684	CDD:304357	99/303 (33%)
		Pkinase_Tyr	397..673	CDD:285015	93/275 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810