DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment FER and blk

DIOPT Version :9

Sequence 1:NP_524288.3 Gene:FER / 41118 FlyBaseID:FBgn0000723 Length:1325 Species:Drosophila melanogaster
Sequence 2:XP_017208000.1 Gene:blk / 567764 ZFINID:ZDB-GENE-040724-106 Length:501 Species:Danio rerio


Alignment Length:503 Identity:162/503 - (32%)
Similarity:246/503 - (48%) Gaps:78/503 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   877 CNCP----PAGQKPVKPSVQISGH--KDHPFESSSGELDENSDRDIDNDEEEEDSASDDVLSMK- 934
            |.|.    |.|.:....:...:.|  :||..:::      |.|.|:...:.:...||::.|..| 
Zfish    19 CACSDQNHPKGHEHYNSTNSKTSHASRDHKKQNN------NQDEDVVIAQYDFQPASENDLQFKK 77

  Fly   935 ----------DHCYCVPSLAA-------SISLSTNRPLYEEEWFHGVLPREEVVRLL----NNDG 978
                      ...:...||..       |..::..:.|..|.||...:.|.:..|||    |..|
Zfish    78 GDRLRIIKENGEWWLAKSLVTGYEGFIPSTYVARAQTLQVERWFFKDMNRRDTERLLLAPGNKPG 142

  Fly   979 DFLVRE----------TIRN---EESQIVLSVCWNGHKHFIVQTTGEGNFRFE-GPPFASIQELI 1029
            .|||||          :||:   |:..:|        ||:.::....|.:... ...|:|:|||:
Zfish   143 SFLVRESETTKGAFSLSIRDSTPEQGDVV--------KHYKIRALDNGGYYISPSTSFSSLQELV 199

  Fly  1030 MHQYHS--------ELPVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAKLKSTK 1086
              :|:|        .|....||.| .:||..::.||:..:.:.|::::|.|.||:|:....|:.:
Zfish   200 --KYYSRTADGLCQRLGNPCKSTA-PQRPWAQDEWEIPRETLKLVKKLGAGQFGEVWMGFYKNNQ 261

  Fly  1087 LDVAVKTCRM-TLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYL 1150
             .||:||.:. |:..|   .||||..::||..|..:|||..: |.::||.||.|.:..||||.:|
Zfish   262 -KVAIKTLKEGTMEPE---AFLQEANLMKQLQHERLVKLHAV-VTREPIYIVTEYMANGSLLDFL 321

  Fly  1151 RKNSNG--LTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSR-EEEE 1212
             |..:|  |...:.:.|....|.||.|:|.||.|||||.|.|.||......||:|||::| .|.|
Zfish   322 -KTDDGHKLKLSKLIDMTAQIAEGMAYIERKNYIHRDLRAANILVSETLHCKIADFGLARIIETE 385

  Fly  1213 YIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGY 1277
            |...:|.| .|:|||||||:|:|.:|...||||:|||:.||.:.|..||.||||......:|..|
Zfish   386 YTAQEGAK-FPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTYGRVPYPGMTNPEVIRNLDRNY 449

  Fly  1278 RMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVDALILRLDNSH 1325
            |||.|.:.|.|:|.:|.:||....|.||.|:.:.:.::...:..:..:
Zfish   450 RMPCPDACPGELYDIMTKCWMEKPEDRPTFEYLQDTLNDFFIATEGQY 497

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FERNP_524288.3 F-BAR_Fes_Fer 7..243 CDD:153341
SH2_Fps_family 953..1039 CDD:198224 30/111 (27%)
TyrKc 1063..1311 CDD:197581 108/251 (43%)
PTKc_Fes_like 1067..1315 CDD:270637 107/251 (43%)
blkXP_017208000.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000006
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.910

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