DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and blk

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_017208000.1	Gene:	blk / 567764	ZFINID:	ZDB-GENE-040724-106	Length:	501	Species:	Danio rerio

Alignment Length:	503	Identity:	162/503 - (32%)
Similarity:	246/503 - (48%)	Gaps:	78/503 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   877 CNCP----PAGQKPVKPSVQISGH--KDHPFESSSGELDENSDRDIDNDEEEEDSASDDVLSMK- 934
            |.|.    |.|.:....:...:.|  :||..:::      |.|.|:...:.:...||::.|..|
Zfish    19 CACSDQNHPKGHEHYNSTNSKTSHASRDHKKQNN------NQDEDVVIAQYDFQPASENDLQFKK 77

  Fly   935 ----------DHCYCVPSLAA-------SISLSTNRPLYEEEWFHGVLPREEVVRLL----NNDG 978
                      ...:...||..       |..::..:.|..|.||...:.|.:..|||    |..|
Zfish    78 GDRLRIIKENGEWWLAKSLVTGYEGFIPSTYVARAQTLQVERWFFKDMNRRDTERLLLAPGNKPG 142

  Fly   979 DFLVRE----------TIRN---EESQIVLSVCWNGHKHFIVQTTGEGNFRFE-GPPFASIQELI 1029
            .|||||          :||:   |:..:|        ||:.::....|.:... ...|:|:|||:
Zfish   143 SFLVRESETTKGAFSLSIRDSTPEQGDVV--------KHYKIRALDNGGYYISPSTSFSSLQELV 199

  Fly  1030 MHQYHS--------ELPVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAKLKSTK 1086
              :|:|        .|....||.| .:||..::.||:..:.:.|::::|.|.||:|:....|:.:
Zfish   200 --KYYSRTADGLCQRLGNPCKSTA-PQRPWAQDEWEIPRETLKLVKKLGAGQFGEVWMGFYKNNQ 261

  Fly  1087 LDVAVKTCRM-TLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYL 1150
             .||:||.:. |:..|   .||||..::||..|..:|||..: |.::||.||.|.:..||||.:|
Zfish   262 -KVAIKTLKEGTMEPE---AFLQEANLMKQLQHERLVKLHAV-VTREPIYIVTEYMANGSLLDFL 321

  Fly  1151 RKNSNG--LTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSR-EEEE 1212
             |..:|  |...:.:.|....|.||.|:|.||.|||||.|.|.||......||:|||::| .|.|
Zfish   322 -KTDDGHKLKLSKLIDMTAQIAEGMAYIERKNYIHRDLRAANILVSETLHCKIADFGLARIIETE 385

  Fly  1213 YIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGY 1277
            |...:|.| .|:|||||||:|:|.:|...||||:|||:.||.:.|..||.||||......:|..|
Zfish   386 YTAQEGAK-FPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTYGRVPYPGMTNPEVIRNLDRNY 449

  Fly  1278 RMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVDALILRLDNSH 1325
            |||.|.:.|.|:|.:|.:||....|.||.|:.:.:.::...:..:..:
Zfish   450 RMPCPDACPGELYDIMTKCWMEKPEDRPTFEYLQDTLNDFFIATEGQY 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	30/111 (27%)
		TyrKc	1063..1311	CDD:197581	108/251 (43%)
		PTKc_Fes_like	1067..1315	CDD:270637	107/251 (43%)
blk	XP_017208000.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910