DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and frk

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_021324228.1	Gene:	frk / 567549	ZFINID:	ZDB-GENE-110411-7	Length:	512	Species:	Danio rerio

Alignment Length:	381	Identity:	139/381 - (36%)
Similarity:	206/381 - (54%)	Gaps:	38/381 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   958 EEWFHGVLPREEVVRLL----NNDGDFLVRETIRNEESQ---IVLSVCWNGH-KHFIVQTTGEGN 1014
            |.|:.....|.:..::|    |..|.||    |||.|||   :.|||..:.. ||:.::....|.
Zfish   119 EPWYFPETKRSDAEKMLISQENKKGAFL----IRNCESQPGELSLSVRDDVKVKHYKIRKLDNGG 179

  Fly  1015 FRFE-GPPFASIQELIMHQYHSELPVTVKSGAILRRPVCRE----------RWELSNDDVVLLER 1068
            :... ...|.:::||:.|....|..:.|:.....::.|..|          :||:....|.||::
Zfish   180 YYLSTARNFPTLRELVEHYSKHEDGLCVRLAEPCKKSVAPETHGLSYNTVDQWEIERSSVKLLKQ 244

  Fly  1069 IGRGNFGDVYKAKLKSTKLDVAVKTCRMTLPDEQKRK-FLQEGRILKQYDHPNIVKLIGICVQKQ 1132
            :|.|.||:|::.....| ..|||||.:   |.....| ||:|.:|:|:..|..:::|..:|..::
Zfish   245 LGAGQFGEVFEGLWNDT-TPVAVKTLK---PGNMDPKDFLREAQIMKKLRHSKLIQLYAVCTLEE 305

  Fly  1133 PIMIVMELVLGGSLLTYLRKNSNGLTTR--QQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDL 1195
            ||.|:.||:..||||.|| :|..|.|.|  .|:.|....|:||.|||.:|.|||||||||.||..
Zfish   306 PIYIITELMSNGSLLEYL-QNDRGATLRMSDQIDMGAQVASGMAYLELQNYIHRDLAARNVLVGD 369

  Fly  1196 EHSVKISDFGMSR------EEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIF 1254
            .:..|::|||::|      |:..|...:|.| .|||||||||:|..|:|...||||:|||::||.
Zfish   370 NNVCKVADFGLARVFQMDNEDNVYEAKEGTK-FPVKWTAPEAINENKFTIKSDVWSFGILLYEIV 433

  Fly  1255 SKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEI 1310
            :.|.|||..|||.:..:::..||||.:|.:..:.:|.:||.||......||.|:.:
Zfish   434 TFGQTPYPTMTNFQVVQQLPKGYRMSSPPNCHKCLYDIMLDCWKDVPADRPTFETL 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	25/89 (28%)
		TyrKc	1063..1311	CDD:197581	109/257 (42%)
		PTKc_Fes_like	1067..1315	CDD:270637	106/253 (42%)
frk	XP_021324228.1	SH3_Src_like	56..109	CDD:212779
		SH2_Src_family	117..212	CDD:199827	26/96 (27%)
		PTKc_Frk_like	230..500	CDD:270653	111/266 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910