DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and matk

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_695792.1	Gene:	matk / 567405	ZFINID:	ZDB-GENE-070705-183	Length:	445	Species:	Danio rerio

Alignment Length:	458	Identity:	143/458 - (31%)
Similarity:	214/458 - (46%)	Gaps:	74/458 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   892 QISGHKDHPFESSSGELDENSDRDI----------------DNDEEEEDSASDDVLSMKDHCYCV 940
            |....||| .:...||:..:.. ||                .|...||...|...|..::.....
Zfish    11 QCVAKKDH-CKPKDGEISYHKG-DILTLVGPGMRKGEYTARHNTTGEEGQVSGSNLREREALRID 73

  Fly   941 PSLAASISLSTNRPLYEEEWFHGVLPREEVVRLL--NNDGDFLVRETIRNEESQIVLSVCWNG-- 1001
            |.|:..            .||||.:..::.|..|  ..||.|||||::|: ....||.||::.
Zfish    74 PKLSLM------------PWFHGKIAGQQAVDKLKPTEDGLFLVRESVRH-PGDFVLCVCFSQKV 125

  Fly  1002 -HKHFIVQTT--GEGNFRFEGPPFASIQELIMHQYHSELPVTVKSGAI---LRRP---------- 1050
             |...|.|..  ...|.:|    |.::.::|  :::|.     ..|||   |.:|
Zfish   126 FHYRVIYQDNKLTIDNMQF----FDNLIDMI--EFYSR-----NRGAIATLLLKPKKKEGLKSAE 179

  Fly  1051 --VCRERWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRIL 1113
              :.:..|.|....:.|.|.||.|.||.|:..:....::.|.:..|.:|     .:.||:|..::
Zfish   180 TKLLKSGWLLDLSKLTLGEIIGEGEFGAVFAGEYTGQRVAVKIIKCDVT-----AQAFLEETSVM 239

  Fly  1114 KQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSN-GLTTRQQMGMCRDAAAGMRYLE 1177
            ....|.|:|.|:|: :....:.||.||:..|:|:.:||.... .::..|.:....|...||.:||
Zfish   240 TNLHHKNLVPLLGV-ILHNGLHIVTELMTKGNLVNFLRSRGRFAVSVIQLLRFALDVCEGMEHLE 303

  Fly  1178 SKNCIHRDLAARNCLVDLEHSVKISDFGMSREEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCD 1242
            ||..:|||||.||.||..:...||||||::|...  :..|..| :||||||||||...|:::..|
Zfish   304 SKKLLHRDLAGRNILVSEDGVAKISDFGLARVGS--MAVDNSK-LPVKWTAPEALKNKKFSTQSD 365

  Fly  1243 VWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHF 1307
            |||||:|:|||||.|..||..||.:..:|.::.||||..|...|.::|.:|..||..:.:.||.|
Zfish   366 VWSYGVLLWEIFSYGRQPYPKMTVNEVKECVEKGYRMDPPDECPADVYSIMTSCWQTEPKKRPSF 430

  Fly  1308 DEI 1310
            .::
Zfish   431 HKL 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	26/92 (28%)
		TyrKc	1063..1311	CDD:197581	95/249 (38%)
		PTKc_Fes_like	1067..1315	CDD:270637	94/245 (38%)
matk	XP_695792.1	SH3_CHK	9..67	CDD:212745	13/57 (23%)
		SH2_csk_like	77..174	CDD:198190	31/120 (26%)
		PTKc_Chk	187..440	CDD:270666	97/256 (38%)
		STYKc	194..437	CDD:214568	95/249 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810