DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and fes

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_005166438.1	Gene:	fes / 566739	ZFINID:	ZDB-GENE-100812-10	Length:	835	Species:	Danio rerio

Alignment Length:	1329	Identity:	345/1329 - (25%)
Similarity:	514/1329 - (38%)	Gaps:	528/1329 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGFSSALQSRAAHEALIVRQDAELRLMETMKRSIQMKAKCDKEYAISLTAVAQQGLKIDRADEMQ 65
            |||:..|.....|.||:..||:||||||.||:.:..:||.|:|:::.|..::..      .::|:
Zfish     1 MGFAEDLWCPQGHAALMKLQDSELRLMEVMKKWMMQRAKSDREFSMQLHQMSAM------VEKME 59

  Fly    66 G----------SLISKSWRSYMDELDHQAKQFKFNAEQLEV-VCDKLTHLSQDKRKARKAYQEEH 119
            |          |..:|||...:.:.:..::..:.:::.|.| ...|||.|.:||::.||.|.|:.
Zfish    60 GTQPGGGLNYISQFNKSWNVLVSQTESLSRIMRKHSDDLMVGPLSKLTLLIRDKQQLRKTYGEQW 124

  Fly   120 AKIAARLNHLTD-EVVRKKSEYQKHLEGYKALRTRFEENYIKAPSRSGRKLDDVRDKYQKACRKL 183
            ..:...:..:|. |:.|.||.|::.:......:.:::|      :...|:.|..::::.||..||
Zfish   125 TLLNQDMCRVTQTELDRLKSSYRQLVRDATYAKKKYQE------ASKDRERDKAKERFIKATLKL 183

  Fly   184 HLTHNEYVLSITEAIEVEKDFR-NVLLPGLLEHQQSVQESFILLWRNILQEAAQYGDLTADKYKE 247
            |..|||||||: :|.:|..... ....|.||...|::||..:|:.:.||||......|..|:...
Zfish   184 HEHHNEYVLSV-KAAQVHHQLHYGQSQPALLGALQTLQEEMVLILKEILQEYFDLSSLIQDEVVS 247

  Fly   248 IQKRIDTVIGSINPTEEYGEFTEKYKTSPTTPLLFQFDETLIQDIPGKLQSSTLTVDNLTVDWLR 312
            :...:...:.:|.|.:||..|.::.::....|...:||.:|:::... |:...|.::.|||:.::
Zfish   248 VHTEMANALKAIQPHKEYDNFIQQNRSRGEVPACVEFDCSLLEEADA-LEPEDLQLNELTVEGIQ 311

  Fly   313 NRLQELEGAVRDCQEKQMKMIEHVNGGSPVANGSIISNGSNTSNGIQSNKDSLCRQSKDLNALRC 377
            :||..:|
Zfish   312 HRLTAVE---------------------------------------------------------- 318

  Fly   378 QEKQKQKLVDMIKCALNEVGCEELPSGCDDDLTLEQ---NFIENGYNNEQQRSNSTSSPGLGIMN 439
                                 ||| .|....|:.:|   |.:|....:|::.:|
Zfish   319 ---------------------EEL-LGLASTLSSQQATVNQLELDLQDEERSAN----------- 350

  Fly   440 ELMRRGGVLTLLRGRGRHFKRKSTPQPATPMTRSRQGRFNKLQPRSQSLGSLSVIRDGNGPSPAR 504
                       :..|...|.::                 |.|:...|.:....|:|       ||
Zfish   351 -----------IGQRVYQFSKR-----------------NALEDSRQQVVLSMVVR-------AR 380

  Fly   505 YEPITNHRLRQAASVHYLGEEIATSSTNPPDLTRLRRTQCSMLCLGEDEEPVVLASPAPLTQLTA 569
            .|          |....|.:::.                    |||.:|.|
Zfish   381 LE----------AQRRLLADKLQ--------------------CLGTNELP-------------- 401

  Fly   570 AVLTNTNNNHIYADLELDKKKDTSPSPECKGEQIQPKKEQIRIEINQTAPQNSIDAHLDRIDELN 634
                         .|.||
Zfish   402 -------------SLGLD----------------------------------------------- 406

  Fly   635 RVLDDRLKRTLQPSDDVNAIESAEENHIQTRKLAKDPDSQTKRSSSSSSECRSSKDTSHSKKRSL 699
               |||:..|                                   ||:||    :|..| |..::
Zfish   407 ---DDRISLT-----------------------------------SSNSE----RDKDH-KHLNI 428

  Fly   700 SFSQKSISNIFSNLKEFSKSPLVRMGKNHILNEEQDAKRTQPSQHHHSSGSDCPTNSSSSSSNNN 764
            ...:..:|::|                             :|
Zfish   429 DVIRNHLSSLF-----------------------------KP----------------------- 441

  Fly   765 NNNKNTSSNSNHSASQSTIITSTITTTITTTTTTTPSKENSRLKFKVPKIQKKSKAIRNTFRSKL 829
               |.|||                                   .|..|:
Zfish   442 ---KYTSS-----------------------------------VFYTPQ---------------- 452

  Fly   830 LNFQLKRSKPCKQCTKRRRIHPSKSVFDFAKEFEVEQPAGSAADEQFCNCPPAGQKPVKPSVQIS 894
                                                            ..||| ..|| |.|:
Zfish   453 ------------------------------------------------QVPPA-LTPV-PDVE-- 465

  Fly   895 GHKDHPFESSSGELDENSDRDIDNDEEEEDSASDDVLSMKDHCYCVPSLAASISLSTNRPLYEEE 959
                                                                      :||.::.
Zfish   466 ----------------------------------------------------------KPLTQQV 472

  Fly   960 WFHGVLPREEVVRLLNNDGDFLVRETIRNEESQIVLSVCWNGH-KHFIVQTTGEGNFRFEGPPFA 1023
            |:||.:||.||..||.|||||||||:...:|  .||||.|.|. :||::|:| :|.:|.:|..|.
Zfish   473 WYHGAIPRMEVQELLKNDGDFLVRESQGKQE--YVLSVHWGGQCRHFLIQST-DGVYRLDGEGFI 534

  Fly  1024 SIQELIMHQYHSELPVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLD 1088
            |:..|:.|.::|...||.::..:|::|:.:::|.|.:|||:|.:.|||||||:|:..:|:|....
Zfish   535 SVPLLVNHLFNSHQTVTKRTEIVLKKPIPKDKWVLEHDDVILGQSIGRGNFGEVFSGRLRSDNTP 599

  Fly  1089 VAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKN 1153
            ||||.||..||.|.|.|||.|.||||||||||||||||:|.|||||.|:||||.||..||:||..
Zfish   600 VAVKACRENLPAEHKNKFLMEARILKQYDHPNIVKLIGVCTQKQPIYIIMELVQGGDFLTFLRTE 664

  Fly  1154 SNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSREEEE--YIVS 1216
            .:.|.:...:.|..:.|:|:.|||||.|||||:|||||||..|..||||||||||||::  |..:
Zfish   665 GHNLKSSMLIRMAENVASGLAYLESKKCIHRDVAARNCLVGEESVVKISDFGMSREEQDGVYSAT 729

  Fly  1217 DGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPY---SGMTNSRARERIDTGYR 1278
            .||||||||||||||||:|:||:..||||:|:|:||.||:|.|||   :.|:|.:.|:.::.|||
Zfish   730 GGMKQIPVKWTAPEALNYGRYTTESDVWSFGVLLWETFSRGVTPYTIPTVMSNQQTRDEVERGYR 794

  Fly  1279 MPTPKSTPEEMYRLMLQCWAADAESRPHF 1307
            ||.|.:.|:|:|.||.|||..|...||.|
Zfish   795 MPAPNNCPDEIYTLMCQCWQYDPRKRPSF 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341	72/248 (29%)
		SH2_Fps_family	953..1039	CDD:198224	39/86 (45%)
		TyrKc	1063..1311	CDD:197581	148/250 (59%)
		PTKc_Fes_like	1067..1315	CDD:270637	146/246 (59%)
fes	XP_005166438.1	F-BAR_Fes	7..243	CDD:153369	72/248 (29%)
		SH2_Fps_family	466..550	CDD:198224	39/86 (45%)
		Pkinase_Tyr	574..830	CDD:285015	148/250 (59%)
		PKc_like	577..831	CDD:304357	146/247 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	309	1.000	Domainoid score	I1305
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	564	1.000	Inparanoid score	I1043
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D255116at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		otm24930
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	1	1.100	-	-	LDO	PTHR24418
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3894
SonicParanoid	1	1.000	-	-		X1749
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	11.000