DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and alk

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_691964.7	Gene:	alk / 563509	ZFINID:	ZDB-GENE-031027-1	Length:	1705	Species:	Danio rerio

Alignment Length:	477	Identity:	140/477 - (29%)
Similarity:	213/477 - (44%)	Gaps:	91/477 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   881 PAGQKPVKPSVQISGHKD---HPFES----SSGELDENSDRDIDNDEEEEDSASDDVLSMKDHCY 938
            |.|:..::|...:.|:.:   :|.::    .||:..|.|:..:...:||...|.|.|       .
Zfish   954 PDGEMYLEPLKGMEGNGEVIINPVQNCSHCESGDCHETSEGMVCYCDEELTLAPDGV-------S 1011

  Fly   939 CVPS--------------LAASISLSTNRPLYEEEWFHGVLPREEVVRLLNNDGDFLVRETIRNE 989
            |:.|              ||..:|:.|:..:              ...||...|..::......|
Zfish  1012 CINSTELPLLPAQPSLSHLALGLSVGTSALI--------------AALLLAVSGVMIMYRRKHTE 1062

  Fly   990 ESQIVLSV----C-WNGHKHFIVQTTGEGNFRFEGPPFASIQELIMHQYHSELPVTVKSGAILRR 1049
            ...|.|.:    | .:..:...:.|....|:.|.|.. ||:.:|      .|:|         ||
Zfish  1063 LQSIQLELQSPDCKLSKLRASTIMTDYNPNYCFGGKT-ASVNDL------KEVP---------RR 1111

  Fly  1050 PVCRERWELSNDDVVLLERIGRGNFGDVYKAKL-----KSTKLDVAVKTCRMTLPDEQKRKFLQE 1109
                        ::.|...:|.|.||:||:...     :.:.:.|||||......::.:..||.|
Zfish  1112 ------------NISLTRGLGHGAFGEVYEGLAVGIPGEPSPMQVAVKTLPEVCSEQDELDFLME 1164

  Fly  1110 GRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLR------KNSNGLTTRQQMGMCRD 1168
            ..|:.::.|.|||:.||:.:|..|..|::||:.||.|.::||      ::.:.||....:.:.||
Zfish  1165 ALIISKFSHQNIVRCIGVSLQALPHFILLELMAGGDLKSFLRETRPRLEHPSSLTMVDLLNIARD 1229

  Fly  1169 AAAGMRYLESKNCIHRDLAARNCLVDLE---HSVKISDFGMSRE--EEEYIVSDGMKQIPVKWTA 1228
            .|.|.:|||....||||:||||||:..:   ...||.||||:|:  ...|....|...:||||..
Zfish  1230 IARGCQYLEENQFIHRDIAARNCLLTCKGPGRVAKIGDFGMARDIYRASYYRKGGRAMLPVKWMP 1294

  Fly  1229 PEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLM 1293
            |||...|.:||..|.||:|:|:|||||.|..||...:|....|.:..|.||..||:.|..:||:|
Zfish  1295 PEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSRSNQEVLEFVTNGGRMDPPKNCPGPVYRIM 1359

  Fly  1294 LQCWAADAESRPHFDEIYNVVD 1315
            .|.|....|.||:|..|...:|
Zfish  1360 TQSWQHQPEDRPNFSTILERID 1381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	15/90 (17%)
		TyrKc	1063..1311	CDD:197581	100/263 (38%)
		PTKc_Fes_like	1067..1315	CDD:270637	100/263 (38%)
alk	XP_691964.7	LDLa	449..475	CDD:197566
		MAM	488..639	CDD:99706
		FXa_inhibition	980..1012	CDD:317114	9/38 (24%)
		PTKc_ALK_LTK	1106..1382	CDD:270632	106/297 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910