DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and map3k10

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_689424.4	Gene:	map3k10 / 560932	ZFINID:	ZDB-GENE-050419-112	Length:	1062	Species:	Danio rerio

Alignment Length:	270	Identity:	85/270 - (31%)
Similarity:	127/270 - (47%)	Gaps:	40/270 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly  1065 LLERIGRGNFGDVYKAKLKSTKLDVAVKTCRMTLPDEQ----KRKFLQEGRILKQYDHPNIVKLI 1125
            |.|.||.|.||.|||...::.  :||||..|.. |||.    .....||.|:.....|.||:.|.
Zfish   167 LEEVIGAGGFGKVYKGVWRAE--EVAVKAARQD-PDEDISATAENVRQEARLFWMLRHRNIIALR 228

  Fly  1126 GICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKN---CIHRDLA 1187
            |:|:::..:.:|||...||:|...|.  ...:..|..:......|.||.||.::.   .|||||.
Zfish   229 GVCLREPNLCLVMEYARGGALNRALA--GKKVPPRVLVNWAVQIATGMDYLHNQTFVPIIHRDLK 291

  Fly  1188 ARNCLV-------DLE-HSVKISDFGMSRE--EEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCD 1242
            :.|.|:       ||. .::||:|||::||  ....:.:.|    ...|.|||.:....::...|
Zfish   292 SSNILILEPVERDDLSGKTLKITDFGLAREWHRTTKMSAAG----TYAWMAPEVIKLSLFSKSSD 352

  Fly  1243 VWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGY-------RMPTPKSTPEEMYRLMLQCWAAD 1300
            |||:|:|:||:.: |:.||      |..:.:...|       .:|.|.:.||...:|:.:||..:
Zfish   353 VWSFGVLLWELLT-GEVPY------REIDALAVAYGVAMNKLTLPIPSTCPEAFAQLLGECWCPN 410

  Fly  1301 AESRPHFDEI 1310
            ...||.|..|
Zfish   411 PRGRPAFGSI 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224
		TyrKc	1063..1311	CDD:197581	85/270 (31%)
		PTKc_Fes_like	1067..1315	CDD:270637	84/268 (31%)
map3k10	XP_689424.4	SH3_MLK1-3	81..138	CDD:212992
		STYKc	165..424	CDD:214568	85/270 (31%)
		STKc_MLK2	170..427	CDD:271050	83/267 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900