DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and MAP2K6

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_011523328.1	Gene:	MAP2K6 / 5608	HGNCID:	6846	Length:	337	Species:	Homo sapiens

Alignment Length:	315	Identity:	77/315 - (24%)
Similarity:	133/315 - (42%)	Gaps:	47/315 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly  1017 FEGPPFASIQELIMHQYHSELPVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAK 1081
            ||.|           |..|..|..:.|.|.:  .:..:.:|:..||:..:..:|||.:|.|.|.:
Human    23 FEQP-----------QTSSTPPRDLDSKACI--SIGNQNFEVKADDLEPIMELGRGAYGVVEKMR 74

  Fly  1082 LKSTKLDVAVKTCRMTLPDEQKRKFLQEGRI-LKQYDHPNIVKLIGICVQKQPIMIVMELVLGGS 1145
            ...:...:|||..|.|:..:::::.|.:..| ::..|.|..|...|...::..:.|.|||:....
Human    75 HVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSL 139

  Fly  1146 LLTYLRKNSNGLTTRQQM--GMCRDAAAGMRYLESK-NCIHRDLAARNCLVDLEHSVKISDFGMS 1207
            ...|.:....|.|..:.:  .:.......:.:|.|| :.||||:...|.|::....||:.|||:|
Human   140 DKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGIS 204

  Fly  1208 REEEEYIVSDGMKQIPV---KWTAPE----ALNFGKYTSLCDVWSYGILMWEI------FSKGDT 1259
                .|:|....|.|..   .:.|||    .||...|:...|:||.||.|.|:      :....|
Human   205 ----GYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGT 265

  Fly  1260 PYSGMTNSRARERIDTGYRMPTPKSTPE----EMYRLMLQCWAADAESRPHFDEI 1310
            |:         :::......|:|:...:    |......||...:::.||.:.|:
Human   266 PF---------QQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPEL 311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	5/21 (24%)
		TyrKc	1063..1311	CDD:197581	66/269 (25%)
		PTKc_Fes_like	1067..1315	CDD:270637	66/265 (25%)
MAP2K6	XP_011523328.1	PKc_MKK3_6	54..336	CDD:173729	68/271 (25%)
MAP2K6	XP_011523328.1	S_TKc	57..317	CDD:214567	66/268 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910