DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and ddr2b

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_017206819.2	Gene:	ddr2b / 559428	ZFINID:	ZDB-GENE-060503-361	Length:	838	Species:	Danio rerio

Alignment Length:	360	Identity:	101/360 - (28%)
Similarity:	171/360 - (47%)	Gaps:	74/360 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  1020 PPFASIQELIM-----------------HQYHSELP------VTV--------KSGAILRRPVCR 1053
            |.|.:::.|.|                 |...:::|      |||        :.||:
Zfish   483 PEFQAMENLAMIDGASEPSPAQGTDEAPHYAEADIPGAHSYRVTVVNMPLSPGRDGAL------- 540

  Fly  1054 ERWELSNDDVVLLERIGRGNFGDVYKAKLKSTK--------------LDVAVKTCRMTLPDEQKR 1104
              .|...|.:...|::|.|.||:|:..:.:..:              :.|||||.|.......:.
Zfish   541 --EEFPRDRLTFKEKLGEGQFGEVHLCEAEGMQEFMKDHCDDICVDPMLVAVKTLREDADKNARN 603

  Fly  1105 KFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRK----------NSNGLTT 1159
            .|::|.||:.:...|||::|:.:||:..|:.::.|.:..|.|..:|.:          :|..::.
Zfish   604 DFMKEIRIISRLRDPNIIRLLAVCVESDPLCMITEYMENGDLNQFLSRHQLQEDGVQADSTSISY 668

  Fly  1160 RQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSRE--EEEYIVSDGMKQI 1222
            ...:.|....::||:||.|.|.:|||||.|||||.:.:.:||:||||||.  ..:|....|...:
Zfish   669 GTLINMASQISSGMKYLSSLNFVHRDLATRNCLVGMNNIIKIADFGMSRNLYRGDYYRIQGRAVL 733

  Fly  1223 PVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSK-GDTPYSGMTNSRARERIDTGYR-------M 1279
            |::|.:.|::..||:|...|||::|:.:|||.:. .:.||:..|:.:..|.....:|       :
Zfish   734 PIRWMSWESILLGKFTMASDVWAFGVTLWEILTLCKEQPYAQFTDEQVIENTGEFFRDQNKQVYL 798

  Fly  1280 PTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVV 1314
            ..|...||.:|.|||.||..:|:.||.|.||::.:
Zfish   799 LRPACCPESLYSLMLNCWRRNAKERPTFLEIHSTL 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	6/41 (15%)
		TyrKc	1063..1311	CDD:197581	87/281 (31%)
		PTKc_Fes_like	1067..1315	CDD:270637	88/282 (31%)
ddr2b	XP_017206819.2	FA58C	28..180	CDD:238014
ddr2b	XP_017206819.2	PTKc_DDR	542..835	CDD:270644	90/292 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910