DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and csk

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001071067.1	Gene:	csk / 556454	ZFINID:	ZDB-GENE-061103-493	Length:	450	Species:	Danio rerio

Alignment Length:	376	Identity:	131/376 - (34%)
Similarity:	198/376 - (52%)	Gaps:	30/376 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   960 WFHGVLPREEVVRLL--NNDGDFLVRETIRNEESQIVLSVCWNGH-KHF-IVQTTGEGNFRFEGP 1020
            ||||.:.||:..|||  ...|.|||||: .|......|.|..:|. :|: |:...|:.:.. |..
Zfish    82 WFHGKITREQAERLLYPPETGLFLVRES-TNYPGDYTLCVSCDGKVEHYRIIYHNGKLSID-EEE 144

  Fly  1021 PFASIQELIMHQYHSEL---------PVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGD 1076
            .|.::.:|:.| |..:.         |..::.....:....|..|.|:..::.|::.||:|.|||
Zfish   145 YFENLMQLMEH-YTKDADGLCTRLIKPKIMEGTVAAQDEFSRSGWALNRKELKLIQTIGKGEFGD 208

  Fly  1077 VYKAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICV-QKQPIMIVMEL 1140
            |.....:..|  ||||..:   .|...:.|:.|..::.|..|.|:|:|:|:.| :|..:.||.|.
Zfish   209 VMVGDYRGKK--VAVKCIK---HDATAQAFVAEASVMTQLRHNNLVQLLGVIVEEKGSLYIVTEY 268

  Fly  1141 VLGGSLLTYLRKNSNGLTT---RQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKIS 1202
            :..|||:.|||  |.|.|.   .:.:....|....|.|||:.|.:||||||||.||..::..|:|
Zfish   269 MAKGSLVDYLR--SRGRTVIGGDRLINFSMDVCKAMEYLEANNFVHRDLAARNVLVSEDNIAKVS 331

  Fly  1203 DFGMSREEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNS 1267
            |||:::|...   :....::|||||:||||...|:::..||||||||:|||:|.|..||..:...
Zfish   332 DFGLTKEASS---TQDTAKLPVKWTSPEALREKKFSTKSDVWSYGILLWEIYSFGRVPYPRIPLK 393

  Fly  1268 RARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVDALI 1318
            ....|::.||:|.:|...|..:|.:|.|||..||..||.|.::...:..:|
Zfish   394 EVVPRVEKGYKMDSPDGCPPVVYDIMKQCWTLDAVVRPSFRDLREKLQDII 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	27/91 (30%)
		TyrKc	1063..1311	CDD:197581	99/251 (39%)
		PTKc_Fes_like	1067..1315	CDD:270637	98/251 (39%)
csk	NP_001071067.1	SH3_CSK	11..67	CDD:212703
		SH2_csk_like	78..175	CDD:198190	28/95 (29%)
		PTKc_Csk	188..443	CDD:133213	101/264 (38%)
		STYKc	195..440	CDD:214568	99/254 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910