DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and ryk

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_012825927.1	Gene:	ryk / 550026	XenbaseID:	XB-GENE-485290	Length:	601	Species:	Xenopus tropicalis

Alignment Length:	326	Identity:	93/326 - (28%)
Similarity:	156/326 - (47%)	Gaps:	41/326 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly  1020 PPFASIQELIMHQYHSELPVTVKSGAILRRPVCR-ERWEL-----------------SNDDVVLL 1066
            |...:.|.|.....::..|||..||    .|..| |:.:|                 |.:.|.|.
Frog   267 PSTQTTQYLRADTPNNATPVTSSSG----YPTLRIEKNDLKSVTLQEAKAKVKDIAISRERVTLK 327

  Fly  1067 ERIGRGNFGDVYKAKLKSTK-----LDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIG 1126
            :.:..|.||.::...|...|     ..|.|||.:....:.|....|.|...|:...|.|::.:..
Frog   328 DVLQEGTFGRIFHGILVDEKDPNKEKAVFVKTVKDQASEVQITMMLTESCKLRGLHHRNLLPIGH 392

  Fly  1127 ICVQ--KQPIMIVMELVLGGSLLTYLRK-------NSNGLTTRQQMGMCRDAAAGMRYLESKNCI 1182
            :|.:  ::| |:::..:..|:|..:||:       |...::.:..:.|....|.||.||..:..|
Frog   393 VCTEDGEKP-MVLLPYMNWGNLKLFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVI 456

  Fly  1183 HRDLAARNCLVDLEHSVKISDFGMSRE---EEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVW 1244
            |:|||||||::|....|||:|..:||:   .:.:.:.|...: ||:|.|.|:|...:::|..|||
Frog   457 HKDLAARNCVIDESLQVKITDNALSRDLFPMDYHCLGDNENR-PVRWMALESLVNKEFSSAGDVW 520

  Fly  1245 SYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDE 1309
            ::|:.:||:.:.|.|||..:........:..|||:..|.:.|:|::.:|..|||.|.|.||.|.:
Frog   521 AFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQ 585

  Fly  1310 I 1310
            :
Frog   586 L 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	3/18 (17%)
		TyrKc	1063..1311	CDD:197581	80/265 (30%)
		PTKc_Fes_like	1067..1315	CDD:270637	78/261 (30%)
ryk	XP_012825927.1	WIF	57..180	CDD:366878
ryk	XP_012825927.1	PTK_Ryk	317..597	CDD:270639	81/272 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910