Protein Alignment FER and fer

DIOPT Version :9

• Sequence 1: NP_524288.3
• Gene: FER / 41118
• FlyBaseID: FBgn0000723
• Length: 1325
• Species: Drosophila melanogaster
• Sequence 2: XP_012818421.1
• Gene: fer / 549656
• XenbaseID: XB-GENE-1015488
• Length: 822
• Species: Xenopus tropicalis
• Alignment Length: 1321
• Identity: 352/1321 - (26%)
• Similarity: 521/1321 - (39%)
• Gaps: 522/1321 - (39%)

  Fly     1 MGFSSALQSRAAHEALIVRQDAELRLMETMKRSIQMKAKCDKEYAISLTAVAQQ-----GLKIDR 60
            |||...|  |::|:||:..||.||||:||:|:.:.::.|.|||||.:|..:..|     .|.:|.
 Frog     1 MGFGKEL--RSSHDALLKLQDWELRLLETVKKFMALRIKSDKEYASTLQNLCNQMDKESALPLDY 63

  Fly    61 ADEMQGSLISKSWRSYMDELDHQAKQFKFNAEQLEV-VCDKLTHLSQDKRKARKAYQEEHAKIAA 124
            .     |.:|.||...:.:.:..:|..|.:||:|.. ...:||.|.:||:..:|:|...|.:|.|
 Frog    64 I-----SNVSNSWLHLVQQTEQLSKIMKTHAEELNAGPLHRLTTLIKDKQHVKKSYNNIHQQIEA 123

  Fly   125 RLNHLT-DEVVRKKSEYQKHLEGYKALRTRFEENYIKAPSRSGRKLDDVRDKYQKACRKLHLTHN 188
            .:|.:: .|:.:.||.|::..:...:.:.:|     |..|..|::.:..||:|.||..|||:.||
 Frog   124 EMNKVSKTELEKLKSSYKQLTKEVNSAKEKF-----KDASTKGKETEKARDRYDKANMKLHILHN 183

  Fly   189 EYVLSITEAIEVEKDFRNVLLPGLLEHQQSVQESFILLWRNILQEAAQYGDLTADKYKEIQKRID 253
            :|||::..|...:..:.:..||.||:..|.:||..|...:.|..|..|...|.:::...:.|.::
 Frog   184 QYVLAVKGAQLHQHQYYDSTLPLLLDSLQKMQEEMIQALKGIFAEYCQITSLVSEEIVAVHKELE 248

  Fly   254 TVIGSINPTEEYGEFTEKYKTSPTTPLLFQFDETLIQDIPGKLQSSTLTVDNLTVDWLRNRLQEL 318
            |.:..|||:.||..|.||::|..|.....:||.:|:::|. .||::.:..:|||.|.|.:.|:.
 Frog   249 TCVEEINPSTEYENFIEKHRTEETREPDIEFDTSLLEEIE-NLQANEIMWNNLTADSLNSMLKT- 311

  Fly   319 EGAVRDCQEKQMKMIEHVNGGSPVANGSIISNGSNTSNGIQSNKDSLCRQSKDLNALRCQEKQKQ 383
              |..:..:.|..::                                           .:|:|..
 Frog   312 --ATEELSQTQQSLL-------------------------------------------TKEEQLS 331

  Fly   384 KLVDMIKCALNEVGCEELPSGCDDDLTLEQNFIENGYNNEQQRSNSTSSPGLGIMNELMRRGGVL 448
            ||         ||..||..|.|:
 Frog   332 KL---------EVNLEESASTCE------------------------------------------ 345

  Fly   449 TLLRGRGRHFKRKSTPQPATPMTRSRQGRFNKLQPRSQSLGSLSVIRDGNGPSPARYEPITNHRL 513
                       :||
 Frog   346 -----------KKS--------------------------------------------------- 348

  Fly   514 RQAASVHYLGEEIATSSTNPPDLTRLRRTQCSMLCLGEDEEPVVLASPAPLTQLTAAVLTNTNNN 578
                                                    :.|:|     |:|..|.
 Frog   349 ----------------------------------------DAVLL-----LSQKQAI-------- 360

  Fly   579 HIYADLELDKKKDTSPSPECKGEQIQPKKEQIRIEINQTAPQNSIDAHLDRIDELNRVLDDRLKR 643
                                  |:::...||::...::.:.|..:             ||.::
 Frog   361 ----------------------EELKQSIEQLKCAESKLSAQKML-------------LDQKI-- 388

  Fly   644 TLQPSDDVNAIESAEENHIQTRKLAKDPDSQTKRSSSSSSECRSSKDTSHSKKRSLSFSQKSISN 708
                          ::|.      .|:|..
 Frog   389 --------------QQNE------GKEPPP----------------------------------- 398

  Fly   709 IFSNLKEFSKSPLVRMGKNHILNEEQDAKRTQPSQHHHSSGSDCPTNSSSSSSNNNNNNKNTSSN 773
                                ::|.|:||:
 Frog   399 --------------------VVNYEEDAR------------------------------------ 407

  Fly   774 SNHSASQSTIITSTITTTITTTTTTTPSKENSRLKFKVPKIQKKSKAIR-NTFRSKLLNFQLKRS 837
                                                .|..:.||.|..: :|||..:...
 Frog   408 ------------------------------------SVCSVDKKEKVSKFDTFRHSIAGI----- 431

  Fly   838 KPCKQCTKRRRIHPSKSVFDFAKEFEVEQPAGSAADEQFCNCPPAGQKPVKPSVQISGHKDHPFE 902
                       |...||:.            ||:
 Frog   432 -----------IRSPKSML------------GSS------------------------------- 442

  Fly   903 SSSGELDENSDRDIDNDEEEEDSASDDVLSMKDHCYCVPSLAASISLSTNRPLYEEEWFHGVLPR 967
                                                   ||...|| :..:||.|::|:||.:||
 Frog   443 ---------------------------------------SLLDGIS-AIEKPLSEQDWYHGAIPR 467

  Fly   968 EEVVRLLNNDGDFLVRETIRNEESQIVLSVCWNG-HKHFIVQTTGEGNFRFEGPPFASIQELIMH 1031
            .|...||...|||||||: ..:..:.||||..:. .:|||:| ..:..:||||..|.:|.:||.|
 Frog   468 VEAQELLKQQGDFLVRES-HGKPGEYVLSVFSDSQRRHFIIQ-FADNQYRFEGTGFPTIPQLIEH 530

  Fly  1032 QYHSELPVTVKSGAILRRPVCRE-RWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCR 1095
            .|.::..:|.|||.:|..||.:: :|.|:::||.|.|.:|:||||:|||..||. |..||||||:
 Frog   531 HYTTKQVITKKSGVVLLNPVVKDKKWILNHEDVTLGELLGKGNFGEVYKGTLKD-KTPVAVKTCK 594

  Fly  1096 MTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTR 1160
            ..||.|.|.|||.|.||||||||.|||||||:|.|:|||.||||||.||..|::|||..:.:.|:
 Frog   595 EDLPQELKIKFLSEARILKQYDHANIVKLIGVCTQRQPIYIVMELVPGGDFLSFLRKKKDDMKTK 659

  Fly  1161 QQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSREEEEYIV-SDGMKQIPV 1224
            |......|||:||.|||||||||||||||||||...:.:|||||||||:|::.|. |.|:||||:
 Frog   660 QLAKFSFDAASGMAYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQEDDGIYSSSGLKQIPI 724

  Fly  1225 KWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEM 1289
            |||||||||:|:|:|..||||:|||:||.||.|..||.||||.:|||:::.||||..|::.|||:
 Frog   725 KWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVEKGYRMSAPQNCPEEV 789

  Fly  1290 YRLMLQCWAADAESRPHFDEI 1310
            :|:|.:||....|:||.|.|:
 Frog   790 FRIMQKCWEYKPENRPKFSEM 810

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341	78/242 (32%)
		SH2_Fps_family	953..1039	CDD:198224	36/86 (42%)
		TyrKc	1063..1311	CDD:197581	153/249 (61%)
		PTKc_Fes_like	1067..1315	CDD:270637	151/245 (62%)
fer	XP_012818421.1	F-BAR_Fer	5..238	CDD:153370	78/244 (32%)
		SH2_Fps_family	453..538	CDD:198224	36/86 (42%)
		PKc_like	566..815	CDD:389743	151/246 (61%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	311	1.000	Domainoid score	I1304
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H74300
Inparanoid	1	1.050	564	1.000	Inparanoid score	I1074
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D255116at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		otm49294
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3894
SonicParanoid	1	1.000	-	-		X1749
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	12.100