DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and ror2

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001015834.1	Gene:	ror2 / 548551	XenbaseID:	XB-GENE-491498	Length:	930	Species:	Xenopus tropicalis

Alignment Length:	317	Identity:	103/317 - (32%)
Similarity:	151/317 - (47%)	Gaps:	46/317 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly  1021 PFASIQELIMHQYHSELPVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAKLKST 1085
            |...::..:|:| |.:.| .||              |::...|..:|.:|...||.|||..|..|
Frog   444 PSQDMEMPLMNQ-HKQQP-KVK--------------EINLSTVRFMEELGEDRFGKVYKGHLFGT 492

  Fly  1086 -----KLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGS 1145
                 ...||:||.:..:....:.:|..|..:..:..|||||.|||...::||    |.:|...|
Frog   493 TPGEQTQTVAIKTLKDKVEVALREEFKHEAMMRSRLQHPNIVCLIGTVTKEQP----MSMVFSYS 553

  Fly  1146 LLTYLRKNSNGLTTRQQMGMCRD-------------------AAAGMRYLESKNCIHRDLAARNC 1191
            .|:.|.:.....:....:|...|                   .||||.:|.|.:.:|:||||||.
Frog   554 PLSDLHEFLVMRSPHSDVGSTDDDKTVKSTLEPTDFLHIVTQIAAGMEFLSSHHVVHKDLAARNV 618

  Fly  1192 LVDLEHSVKISDFGMSRE--EEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIF 1254
            ||..:.||||||.|:.||  ..:|....|...:|::|.:|||:.:||.:...|:||||:|:||||
Frog   619 LVFDKLSVKISDLGLFREVYAADYYKLMGNSMLPIRWMSPEAITYGKCSVDSDIWSYGVLLWEIF 683

  Fly  1255 SKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIY 1311
            |.|..||.|.:|....|.:.....:..|...|..:|.|||:||:.....||.|.:|:
Frog   684 SYGLQPYCGYSNQDVIEMVRNRQVLLCPDDCPAWIYTLMLECWSEFPARRPRFKDIH 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	4/17 (24%)
		TyrKc	1063..1311	CDD:197581	94/273 (34%)
		PTKc_Fes_like	1067..1315	CDD:270637	94/271 (35%)
ror2	NP_001015834.1	I-set	62..150	CDD:369462
		CRD_TK_ROR2	168..305	CDD:143577
		KR	310..390	CDD:214527
		PKc_like	463..746	CDD:389743	97/296 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910