DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and hck

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001015722.1	Gene:	hck / 548439	XenbaseID:	XB-GENE-6048191	Length:	498	Species:	Xenopus tropicalis

Alignment Length:	387	Identity:	133/387 - (34%)
Similarity:	209/387 - (54%)	Gaps:	22/387 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   955 LYEEEWFHGVLPREEVVRL----LNNDGDFLVRETIRNEESQIVLSVCWNGH--KHFIVQTTGEG 1013
            |..:||:...:.|:|..|.    ||..|.|::|:: ...:....|||..:|.  :|:.::|..:|
Frog   114 LESKEWYFKDMGRKEAERQLLSPLNTCGAFMIRDS-ETTKGSFSLSVRDSGDTVRHYKIRTHEDG 177

  Fly  1014 NFRFEGP-PFASIQELIMHQYHSELP-----VTVKSGAIL-RRPVCRERWELSNDDVVLLERIGR 1071
            .|..... .|.|:.||:.| |..::.     :||....:. .:|..::.||:..:.:.|.:::|.
Frog   178 GFFISTRITFPSLPELVSH-YQGKMSGLCQCLTVPCQTLRPEKPWEKDAWEIPRESLSLQKKLGT 241

  Fly  1072 GNFGDVYKAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMI 1136
            |.||||:.|.... ..:|||||  |.........||:|..::|...|..:|:|..:..|.:||.|
Frog   242 GQFGDVWLATYNG-HTEVAVKT--MKAGSMSPAAFLEEANLMKSLQHERLVRLHAVVTQGEPIYI 303

  Fly  1137 VMELVLGGSLLTYLRK-NSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVK 1200
            |.|.:..||||.:|:. ..:.....|.:..|...|.||.::|.:|.|||||.|.||||......|
Frog   304 VTEYMHKGSLLDFLKSPEGSRQPVTQLIDFCAQIAEGMWFIEQRNYIHRDLRAANCLVSETLLCK 368

  Fly  1201 ISDFGMSR--EEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSG 1263
            |:|||::|  |:.||...:|.| .|:|||:|||.|:|.:|...|:||:|:|:.||.:.|.:||.|
Frog   369 IADFGLARVIEDSEYTAREGSK-FPIKWTSPEAANYGSFTIKSDIWSFGVLLSEIMTYGRSPYPG 432

  Fly  1264 MTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVDALILRLDNSH 1325
            |:||.....::.|||||.|.:.|.|:|.:|||||..|...||.|:.:.|:::...:..:..:
Frog   433 MSNSEVMAALERGYRMPCPGTCPTELYGIMLQCWQQDPHKRPTFEYLQNILEDFFIGTETQY 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	25/95 (26%)
		TyrKc	1063..1311	CDD:197581	102/250 (41%)
		PTKc_Fes_like	1067..1315	CDD:270637	102/250 (41%)
hck	NP_001015722.1	SH3	57..112	CDD:388381
		SH2_Src_family	115..211	CDD:199827	25/97 (26%)
		PTKc_Src_like	237..484	CDD:270630	102/250 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000