DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and Tyk2

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001192241.1	Gene:	Tyk2 / 54721	MGIID:	1929470	Length:	1207	Species:	Mus musculus

Alignment Length:	427	Identity:	118/427 - (27%)
Similarity:	178/427 - (41%)	Gaps:	97/427 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   963 GVLPREEVVRLLNNDGDFLVRETIRNEESQI------------VLSVCWNGHKHFIVQTTGEGNF 1015
            |.|.|||.|..:    .:...|.:....|.:            :|.:|::          ||...
Mouse   785 GALSREERVERI----PWTAPECLSGGTSSLGTATDMWGFGATLLEICFD----------GEAPL 835

  Fly  1016 RFEGPPFASIQELIMHQYHSELP-------VTVKSGAILRRPVCRERWEL--------------- 1058
            :..||   |.:|....:.| :||       .|:....:...|..|..:..
Mouse   836 QGRGP---SEKERFYTKKH-QLPEPSSPELATLTRQCLTYEPAQRPSFRTILRDLTRLQPQNLVG 896

  Fly  1059 ---------SNDDVVLLER-------IGRGNFGDV----YKAKLKSTKLDVAVKTCRMTLPDEQK 1103
                     ::|..|..:|       :|.|:||.|    |......|...||||..:.....:.:
Mouse   897 TSAVNSDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLR 961

  Fly  1104 RKFLQEGRILKQYDHPNIVKLIGICVQ--KQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMC 1166
            ..:.:|..||:...|.:|||..|.|..  ::.:.:|||.|..|||..||.::..||.  |.:...
Mouse   962 SGWQREIEILRTLYHEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHCVGLA--QLLLFA 1024

  Fly  1167 RDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSR---EEEEY--IVSDGMKQIPVKW 1226
            :....||.||.:::.|||||||||.|:|.:..|||.|||:::   |..||  :..||  ..||.|
Mouse  1025 QQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDG--DSPVFW 1087

  Fly  1227 TAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYS--------------GMTNSRARERIDTGY 1277
            .|||.|...|:....||||:|:.::|:.:..|:..|              .||..|..|.::.|.
Mouse  1088 YAPECLKECKFYYASDVWSFGVTLYELLTYCDSNQSPHMKFTELIGHTQGQMTVLRLTELLERGE 1152

  Fly  1278 RMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVV 1314
            |:|.|...|.|:|.||..||..:|..||.|..:..::
Mouse  1153 RLPRPDRCPCEIYHLMKNCWETEASFRPTFQNLVPIL 1189

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	19/94 (20%)
		TyrKc	1063..1311	CDD:197581	95/279 (34%)
		PTKc_Fes_like	1067..1315	CDD:270637	94/280 (34%)
Tyk2	NP_001192241.1	B41	45..299	CDD:214604
		PH-like	296..459	CDD:302622
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	317..391
		SH2	459..557	CDD:301589
		PKc_like	612..887	CDD:304357	22/119 (18%)
		Pkinase_Tyr	612..886	CDD:285015	22/118 (19%)
		PTKc_Tyk2_rpt2	912..1194	CDD:270664	94/282 (33%)
		TyrKc	917..1189	CDD:197581	93/275 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810