DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and PDGFRA

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001334757.1	Gene:	PDGFRA / 5156	HGNCID:	8803	Length:	1114	Species:	Homo sapiens

Alignment Length:	950	Identity:	211/950 - (22%)
Similarity:	332/950 - (34%)	Gaps:	284/950 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   534 PDLTRLRRTQCSMLCLGEDEEPVVL--ASPAPLTQLTAAVLTNTNNNHIYADLELDKKKDTSPS- 595
            ||:..:.......|.:.||::..::  .:..|.|.:|      .:|:........|.::..:.:
Human   149 PDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVT------LHNSEGVVPASYDSRQGFNGTF 207

  Fly   596 ---PECKGEQIQPKKEQ-IRIEINQTAPQNSIDAHLDRIDEL---------------NRVLDDRL 641
               |......::.||.| |...:......:.:|..::.:..:               |.|:|  |
Human   208 TVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKSGETIVVTCAVFNNEVVD--L 270

  Fly   642 KRTLQPSDDVNAIESAEENHIQTRKLAKD---PDSQTKRSSSSSSEC---RSSKDTSHSKKRSLS 700
            :.|.........|...||..:.:.||...   |::..|  .|...||   :::::....||.::|
Human   271 QWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVK--DSGDYECAARQATREVKEMKKVTIS 333

  Fly   701 FSQKSISNIFSNLK-EFSKSPLVRMGK-NHILNEEQDAKRTQPSQHHHSSGSDCPTNSSSSSSNN 763
            ..:|.    |..:| .||:...|.:.: .|.:.|    .|..|           |...|...:|
Human   334 VHEKG----FIEIKPTFSQLEAVNLHEVKHFVVE----VRAYP-----------PPRISWLKNN- 378

  Fly   764 NNNNKNTSSNSNHSASQSTIITSTITTTITTTTTTTPSKENSRLKFKVPKIQKKSK-------AI 821
                                  .|:...:|..||.....:..|.:.|:..|:.|.:       ..
Human   379 ----------------------LTLIENLTEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVA 421

  Fly   822 RNTFRSKLLNFQLKRSKPCKQCTKRRRIHPSKSVFDFAKEFEVEQPAGSAADEQFCNCPPAGQKP 886
            :|....|...|:|....|             .|:.|.     |:...||... |...|...| .|
Human   422 QNEDAVKSYTFELLTQVP-------------SSILDL-----VDDHHGSTGG-QTVRCTAEG-TP 466

  Fly   887 VKPSVQISGHKDHPFESSSGELD----ENSDRDIDNDEEEEDSASDD---VLSMKDHCYCVPSLA 944
            : |.::....||  .:..:.|..    .|:..:|..:....|.::.:   ..:..:....|..||
Human   467 L-PDIEWMICKD--IKKCNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFAKVEETIAVRCLA 528

  Fly   945 ASISLSTNRPLYEEEWFHGVLPREEVVRLLNNDGDFLVRETIRNE---------------ESQIV 994
            .::..:.||.|.                        ||..|:|:|               .|.||
Human   529 KNLLGAENRELK------------------------LVAPTLRSELTVAAAVLVLLVIVIISLIV 569

  Fly   995 LSVCWNGHKHFIVQTTGEGNFRFEGPPFASIQELIMHQYHSELPVTVKSGAILRRPVCRERWELS 1059
            |.|.|.....:.::.....:...:|..:..:..:       :||..             .|||..
Human   570 LVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPM-------QLPYD-------------SRWEFP 614

  Fly  1060 NDDVVLLERIGRGNFGDV-----YKAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQY-DH 1118
            .|.:||...:|.|.||.|     |........:.||||..:.|....:|:..:.|.:|:... .|
Human   615 RDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPH 679

  Fly  1119 PNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRK------------------------------- 1152
            .|||.|:|.|.:..||.|:.|....|.|:.||.|
Human   680 LNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRS 744

  Fly  1153 ----------------------------------------------------------------- 1152

Human   745 YVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSD 809

  Fly  1153 -NSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSRE--EEEYI 1214
             ||.|||....:......|.||.:|.||||:||||||||.|:.....|||.|||::|:  .:...
Human   810 DNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNY 874

  Fly  1215 VSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSG-MTNSRARERIDTGYR 1278
            ||.|...:||||.|||::....||:|.||||||||:|||||.|.|||.| |.:|....:|.:|||
Human   875 VSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYR 939

  Fly  1279 MPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVDALI 1318
            |..|.....|:|.:|::||.::.|.||.|..:..:|:.|:
Human   940 MAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLL 979

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	15/100 (15%)
		TyrKc	1063..1311	CDD:197581	109/353 (31%)
		PTKc_Fes_like	1067..1315	CDD:270637	107/353 (30%)
PDGFRA	NP_001334757.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910