DRSC/TRiP Functional Genomics Resources

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Protein Alignment FER and Ptk2b

DIOPT Version :9

Sequence 1:NP_524288.3 Gene:FER / 41118 FlyBaseID:FBgn0000723 Length:1325 Species:Drosophila melanogaster
Sequence 2:NP_059014.2 Gene:Ptk2b / 50646 RGDID:628758 Length:1009 Species:Rattus norvegicus


Alignment Length:326 Identity:120/326 - (36%)
Similarity:177/326 - (54%) Gaps:25/326 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly  1002 HK-HFIVQTTGEGNFRFEGP--PFASIQELIMH---------QYHSELPVTVKSGAILRRPVCRE 1054
            || ..|:....:|..|...|  |..:::....|         ..::|:|     ...|||| ...
  Rat   358 HKGSLIIHAKKDGEKRNSLPQIPTLNLESRRSHLSESCSIESDIYAEIP-----DETLRRP-GGP 416

  Fly  1055 RWELSNDDVVLLERIGRGNFGDVYK---AKLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQY 1116
            ::.::.:||||...:|.|.||:||:   ...|..|::||||||:.....:.|.||:.|..|:|..
  Rat   417 QYGVAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNL 481

  Fly  1117 DHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKNC 1181
            |||:||||||| ::::|..|||||...|.|..||.:|.|.|.....:.........|.||||.||
  Rat   482 DHPHIVKLIGI-IEEEPTWIVMELYPYGELGHYLERNKNSLKVPTLVLYALQICKAMAYLESINC 545

  Fly  1182 IHRDLAARNCLVDLEHSVKISDFGMSR--EEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVW 1244
            :|||:|.||.||.....||:.|||:||  |:|:|..: .:.::|:||.:||::||.::|:..|||
  Rat   546 VHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKA-SVTRLPIKWMSPESINFRRFTTASDVW 609

  Fly  1245 SYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDE 1309
            .:.:.||||.|.|..|:..:.|......::.|.|:|.|:..|..:|.||.:||..|...||.|.|
  Rat   610 MFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPELCPPVLYTLMTRCWDYDPSDRPRFTE 674

  Fly  1310 I 1310
            :
  Rat   675 L 675

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FERNP_524288.3 F-BAR_Fes_Fer 7..243 CDD:153341
SH2_Fps_family 953..1039 CDD:198224 9/48 (19%)
TyrKc 1063..1311 CDD:197581 105/253 (42%)
PTKc_Fes_like 1067..1315 CDD:270637 102/249 (41%)
Ptk2bNP_059014.2 FERM_N_2 39..137 CDD:407875
B41 41..254 CDD:214604
FERM_C_FAK1 261..368 CDD:270011 3/9 (33%)
PTKc_FAK 418..687 CDD:133187 106/260 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 702..725
Interaction with TGFB1I1. /evidence=ECO:0000269|PubMed:9422762 801..1009
Focal adhesion targeting (FAT) 868..1009
Focal_AT 872..1001 CDD:397606
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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