DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and src

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_017953215.1	Gene:	src / 496893	XenbaseID:	XB-GENE-489820	Length:	544	Species:	Xenopus tropicalis

Alignment Length:	402	Identity:	141/402 - (35%)
Similarity:	211/402 - (52%)	Gaps:	52/402 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   940 VPS--LAASISLSTNRPLYEEEWFHGVLPREEVVRLL----NNDGDFLVRE----------TIRN 988
            :||  :|.|.|:..      |||:.|.:.|.|..|||    |..|.|||||          ::.:
Frog   139 IPSNYVAPSDSIQA------EEWYLGKITRREAERLLLSLENPRGTFLVRESETTKGAYCLSVSD 197

  Fly   989 EESQIVLSVCWNGHKHFIVQTTGEGNFRFEG-PPFASIQELIMHQYHSE--------LPVTVKSG 1044
            .::...|:|     ||:.::....|.|.... ..|:|:|:|:  .|:|:        |.....:.
Frog   198 YDANRGLNV-----KHYKIRKLDSGGFYITSRTQFSSLQQLV--AYYSKHADGLCHRLTTVCPTA 255

  Fly  1045 AILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAKLKST---KLDVAVKTCRM-TLPDEQKRK 1105
            ....:.:.::.||:..|.:.|..::|:|.||:|:......|   ...||:||.:. |:..|   .
Frog   256 KPQTQGLSKDAWEIPRDSLRLELKLGQGCFGEVWMGVSVGTWNGTTRVAIKTLKPGTMSPE---A 317

  Fly  1106 FLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNG--LTTRQQMGMCRD 1168
            ||||.:::|:..|..:|:|..: |.::||.||.|.:..||||.:| |...|  |...|.:.|...
Frog   318 FLQEAQVMKKLRHEKLVQLYAV-VSEEPIYIVTEYMSKGSLLDFL-KGEMGRYLRLPQLVDMAAQ 380

  Fly  1169 AAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSR--EEEEYIVSDGMKQIPVKWTAPEA 1231
            .|:||.|:|..|.:||||.|.|.||......|::|||::|  |:.||....|.| .|:|||||||
Frog   381 IASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAK-FPIKWTAPEA 444

  Fly  1232 LNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQC 1296
            ..:|::|...||||:|||:.|:.:||..||.||.|....::::.|||||.|...||.::.||.||
Frog   445 ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPDCPESLHDLMCQC 509

  Fly  1297 WAADAESRPHFD 1308
            |..|.|.||.|:
Frog   510 WRKDPEERPTFE 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	29/108 (27%)
		TyrKc	1063..1311	CDD:197581	104/254 (41%)
		PTKc_Fes_like	1067..1315	CDD:270637	103/250 (41%)
src	XP_017953215.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.000