DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and DDR2

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001014796.1	Gene:	DDR2 / 4921	HGNCID:	2731	Length:	855	Species:	Homo sapiens

Alignment Length:	447	Identity:	125/447 - (27%)
Similarity:	196/447 - (43%)	Gaps:	101/447 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   911 NSDRDIDNDEEEEDSASDDVLSMKDHCYCVPSLAASISLSTNRPLYEEEWFHGVLPREEVVRLLN 975
            |::|.....|:..:|..|.:..:                   ||.|:|.           .||:.
Human   455 NNNRSSSPSEQGSNSTYDRIFPL-------------------RPDYQEP-----------SRLIR 489

  Fly   976 NDGDFLVRETIRNEESQIVLSVCWNGHKHFIVQTTG-EGNFRFEGPPFASIQELIMHQYHSELPV 1039
            ...:|...|    |||.     |....|.  ||.:| ||...:......::|.:.....:|...|
Human   490 KLPEFAPGE----EESG-----CSGVVKP--VQPSGPEGVPHYAEADIVNLQGVTGGNTYSVPAV 543

  Fly  1040 TVKSGAILRRPVCRERWELSNDDVVL----------LERIGRGNFGDVY--------KAKLKSTK 1086
            |:..              ||..||.:          .|::|.|.||:|:        |.|.|...
Human   544 TMDL--------------LSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFA 594

  Fly  1087 LD--------VAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLG 1143
            ||        ||||..|.......:..||:|.:|:.:...|||:.|:.:|:...|:.::.|.:..
Human   595 LDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMEN 659

  Fly  1144 GSLLTYLRK----NSNGLTTR-----QQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSV 1199
            |.|..:|.:    ||:....|     ....|....|:||:||.|.|.:|||||.|||||...:::
Human   660 GDLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTI 724

  Fly  1200 KISDFGMSRE--EEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFS-KGDTPY 1261
            ||:||||||.  ..:|....|...:|::|.:.|::..||:|:..|||::|:.:||.|: ..:.||
Human   725 KIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPY 789

  Fly  1262 SGMTNSRARERIDTGYR-------MPTPKSTPEEMYRLMLQCWAADAESRPHFDEIY 1311
            |.:::.:..|.....:|       :|.|...|:.:|:|||.||..|.::||.|.||:
Human   790 SQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIH 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	20/86 (23%)
		TyrKc	1063..1311	CDD:197581	94/292 (32%)
		PTKc_Fes_like	1067..1315	CDD:270637	94/280 (34%)
DDR2	NP_001014796.1	FA58C	32..184	CDD:238014
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	452..471		4/15 (27%)
		PTKc_DDR2	557..851	CDD:270677	94/290 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910