DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and ROR2

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_004551.2	Gene:	ROR2 / 4920	HGNCID:	10257	Length:	943	Species:	Homo sapiens

Alignment Length:	279	Identity:	92/279 - (32%)
Similarity:	141/279 - (50%)	Gaps:	24/279 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly  1057 ELSNDDVVLLERIGRGNFGDVYKAKL------KSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQ 1115
            |:|...|..:|.:|...||.|||..|      :.|:. ||:||.:.......:.:|..|..:..:
Human   467 EISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQA-VAIKTLKDKAEGPLREEFRHEAMLRAR 530

  Fly  1116 YDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYL---------------RKNSNGLTTRQQMGM 1165
            ..|||:|.|:|:..:.||:.::......|.|..:|               |...:.|.....:.:
Human   531 LQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHL 595

  Fly  1166 CRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSRE--EEEYIVSDGMKQIPVKWTA 1228
            ....||||.||.|.:.:|:|||.||.||..:.:|||||.|:.||  ..:|....|...:|::|.|
Human   596 VAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIRWMA 660

  Fly  1229 PEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLM 1293
            |||:.:||::...|:||||:::||:||.|..||.|.:|....|.|.....:|.|...|..:|.||
Human   661 PEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPAWVYALM 725

  Fly  1294 LQCWAADAESRPHFDEIYN 1312
            ::||......||.|.:|::
Human   726 IECWNEFPSRRPRFKDIHS 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224
		TyrKc	1063..1311	CDD:197581	89/270 (33%)
		PTKc_Fes_like	1067..1315	CDD:270637	89/269 (33%)
ROR2	NP_004551.2	I-set	64..152	CDD:254352
		IGc2	75..141	CDD:197706
		CRD_TK_ROR2	170..309	CDD:143577
		KR	314..395	CDD:214527
		PTKc_Ror2	466..749	CDD:270673	92/279 (33%)
		Pkinase_Tyr	473..746	CDD:285015	90/273 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	757..796
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	850..931
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910