DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and ROR1

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_005003.2	Gene:	ROR1 / 4919	HGNCID:	10256	Length:	937	Species:	Homo sapiens

Alignment Length:	281	Identity:	96/281 - (34%)
Similarity:	140/281 - (49%)	Gaps:	30/281 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly  1057 ELSNDDVVLLERIGRGNFGDVYKAKLKSTKLD----VAVKTCRMTLPDEQKRKFLQEGRILKQYD 1117
            ||....|..:|.:|...||.:||..|....:|    ||:||.:.....:|..:|.||..::.:..
Human   467 ELPLSAVRFMEELGECAFGKIYKGHLYLPGMDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELH 531

  Fly  1118 HPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRD-------------- 1168
            |||||.|:|...|:||:.::.|.:..|.|..:|...|    ....:|...|
Human   532 HPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRS----PHSDVGCSSDEDGTVKSSLDHGDF 592

  Fly  1169 ------AAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSRE--EEEYIVSDGMKQIPVK 1225
                  .||||.||.|...:|:||||||.|:..:..|||||.|:|||  ..:|........:|::
Human   593 LHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSLLPIR 657

  Fly  1226 WTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMY 1290
            |..|||:.:||::|..|:||:|:::|||||.|..||.|.:|....|.:.....:|..:..|..||
Human   658 WMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMY 722

  Fly  1291 RLMLQCWAADAESRPHFDEIY 1311
            .||.:||......||.|.:|:
Human   723 SLMTECWNEIPSRRPRFKDIH 743

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224
		TyrKc	1063..1311	CDD:197581	93/273 (34%)
		PTKc_Fes_like	1067..1315	CDD:270637	93/271 (34%)
ROR1	NP_005003.2	IG_like	66..148	CDD:214653
		CRD_TK_ROR1	166..307	CDD:143576
		KR	311..393	CDD:214527
		PTKc_Ror1	467..749	CDD:270672	96/281 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	753..779
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	833..890
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910