DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and MUSK

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_005252051.1	Gene:	MUSK / 4593	HGNCID:	7525	Length:	879	Species:	Homo sapiens

Alignment Length:	952	Identity:	209/952 - (21%)
Similarity:	352/952 - (36%)	Gaps:	256/952 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   518 SVHYLGEEIAT-------------SSTNPPDLTRLRRTQCSMLCLGEDEEPVVLASPAPLTQLTA 569
            :|..|.||:||             |.|....|.:|..|:.|   :.|:.:.:.:.|   :.....
Human    36 TVDALVEEVATFMCAVESYPQPEISWTRNKILIKLFDTRYS---IRENGQLLTILS---VEDSDD 94

  Fly   570 AVLTNTNNNHIYADLELDKKKDTSPSPECKGEQIQPKKEQIRIEINQTAPQNSIDAHLDRIDELN 634
            .:...|.||.:...:|           .|...|::.|.:..|..||           :..|:.|.
Human    95 GIYCCTANNGVGGAVE-----------SCGALQVKMKPKITRPPIN-----------VKIIEGLK 137

  Fly   635 RVLDDRLKRTLQPS----------DDVNAIESAEENHIQTRKLAKDPDSQTKRSSSSSSEC--RS 687
            .||........:||          .:.:.|...|...::...:.|:...|.:        |  ::
Human   138 AVLPCTTMGNPKPSVSWIKGDSPLRENSRIAVLESGSLRIHNVQKEDAGQYR--------CVAKN 194

  Fly   688 SKDTSHSKKRSLSFSQKSISNIFSNLKEFSKSPLVRMGKNHILNEEQDAK-----RTQPSQHH-- 745
            |..|::||...|...::|                         ..|||.|     ...|..|:
Human   195 SLGTAYSKVVKLEVEEES-------------------------EPEQDTKVFARILRAPESHNVT 234

  Fly   746 -------HSSGSDCPTNSSSSSSNNNNNNKNTSSNSNHSASQSTIITSTITTTIT-----TTTTT 798
                   |.:.:..|..:.:...|.|    ..||.|...:.:..:|.|.:...||     |...|
Human   235 FGSFVTLHCTATGIPVPTITWIENGN----AVSSGSIQESVKDRVIDSRLQLFITKPGLYTCIAT 295

  Fly   799 TPSKENSRLKFKVPKI------------QKKSKAIRNTFRSKLLNFQLKRSKPCKQCTKRRRIHP 851
            ....|    ||...|.            ||.:|.....:|.::.|..|  :|............|
Human   296 NKHGE----KFSTAKAAATISIAEWSKPQKDNKGYCAQYRGEVCNAVL--AKDALVFLNTSYADP 354

  Fly   852 SKS----VFDFAKEFEVEQP-AGSAADEQFCN-----CPPAGQKPVKPSV---------QISGHK 897
            .::    |.....|.:|..| ...||:...||     |.| |..|....:         ::...|
Human   355 EEAQELLVHTAWNELKVVSPVCRPAAEALLCNHIFQECSP-GVVPTPIPICREYCLAVKELFCAK 418

  Fly   898 DHPFESSSGELDENSDRDIDNDEEEEDSASDDVLSMKDHCYCVPSL------AASI--------S 948
            :...      ::|.:.|.:...|..       :||:.: |..:||:      .|.:        :
Human   419 EWLV------MEEKTHRGLYRSEMH-------LLSVPE-CSKLPSMHWDPTACARLPHLDYNKEN 469

  Fly   949 LSTNRPLYEEEWFHGVLPREEVVRL-LNNDGDFLVRETIRNEESQIVLSV--------------- 997
            |.|..|:...:      |..::..| .::...|.|..|.   ...:::|:
Human   470 LKTFPPMTSSK------PSVDIPNLPSSSSSSFSVSPTY---SMTVIISIMSSFAIFVLLTITTL 525

  Fly   998 --C-----WNGHKH---FIVQTTGEGNFRFEGPPFASIQELIMHQYHSELPVTVKSGAILRRPVC 1052
              |     |...|.   .:..||             ...||::.:.|.. |:..:...:|...:.
Human   526 YCCRRRKQWKNKKRESAAVTLTT-------------LPSELLLDRLHPN-PMYQRMPLLLNPKLL 576

  Fly  1053 RERWELSNDDVVLLERIGRGNFGDVYKAKLKSTK-----LDVAVKTCRMTLPDEQKRKFLQEGRI 1112
            ...:..:|.:.|  ..||.|.||.|::|:.....     ..||||..:.....:.:..|.:|..:
Human   577 SLEYPRNNIEYV--RDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAAL 639

  Fly  1113 LKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRK--------------------NSNG- 1156
            :.::|:||||||:|:|...:|:.::.|.:..|.|..:||.                    :|.|
Human   640 MAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQVSSPGP 704

  Fly  1157 --LTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSRE--EEEYIVSD 1217
              |:..:|:.:.|..||||.||..:..:|||||.|||||.....|||:|||:||.  ..:|..::
Human   705 PPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKAN 769

  Fly  1218 GMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTP 1282
            ....||::|..||::.:.:||:..|||:||:::|||||.|..||.||.:......:..|..:..|
Human   770 ENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCP 834

  Fly  1283 KSTPEEMYRLMLQCWAADAESRPHFDEIYNVVDALILRLDNS 1324
            ::.|.|:|.||..||:.....||.|..|:.:::.:..|.:.:
Human   835 ENCPVELYNLMRLCWSKLPADRPSFTSIHRILERMCERAEGT 876

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	15/111 (14%)
		TyrKc	1063..1311	CDD:197581	93/277 (34%)
		PTKc_Fes_like	1067..1315	CDD:270637	93/277 (34%)
MUSK	XP_005252051.1	I-set	28..117	CDD:254352	19/97 (20%)
		Ig	36..117	CDD:299845	19/97 (20%)
		I-set	121..203	CDD:254352	17/100 (17%)
		Ig	135..201	CDD:299845	12/73 (16%)
		I-set	223..306	CDD:254352	18/90 (20%)
		Ig	239..306	CDD:143165	16/74 (22%)
		CRD_FZ	325..467	CDD:295308	27/158 (17%)
		PTKc_Musk	579..868	CDD:133181	95/290 (33%)
		Pkinase_Tyr	585..866	CDD:285015	94/282 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910