DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and Abl

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001261962.1	Gene:	Abl / 45821	FlyBaseID:	FBgn0000017	Length:	1723	Species:	Drosophila melanogaster

Alignment Length:	384	Identity:	137/384 - (35%)
Similarity:	211/384 - (54%)	Gaps:	32/384 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   955 LYEEEWFHGVLPREEVVRLLNN--DGDFLVRETIRNEESQIVLSVCWNGH-KHFIVQTTGEGN-F 1015
            |.:..|:||.:.|.....||::  :|.|||||: .:...|..:|:.:.|. .|:.:....:|. |
  Fly   267 LEKHSWYHGPISRNAAEYLLSSGINGSFLVRES-ESSPGQRSISLRYEGRVYHYRISEDPDGKVF 330

  Fly  1016 RFEGPPFASIQEL-----IMHQYHSELPVTVKSGAILRRPVC------RERWELSNDDVVLLERI 1069
            ..:...|.::.||     :.|:.|..:...:.......:|..      .:.||:...|:::..::
  Fly   331 VTQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQNKPTVFPLSPEPDEWEICRTDIMMKHKL 395

  Fly  1070 GRGNFGDVYKAKLKSTKLDVAVKTCR---MTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQK 1131
            |.|.:|:||:|..|.....|||||.:   |.|.|     ||:|..|:|:..|||:|:|||:|.::
  Fly   396 GGGQYGEVYEAVWKRYGNTVAVKTLKEDTMALKD-----FLEEAAIMKEMKHPNLVQLIGVCTRE 455

  Fly  1132 QPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMG---MCRDAAAGMRYLESKNCIHRDLAARNCLV 1193
            .|..|:.|.:..|:||.:||  |.|..|...:.   |....|:||.||||:|.||||||||||||
  Fly   456 PPFYIITEFMSHGNLLDFLR--SAGRETLDAVALLYMATQIASGMSYLESRNYIHRDLAARNCLV 518

  Fly  1194 DLEHSVKISDFGMSR--EEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSK 1256
            .....||::|||::|  .::.|....|.| .|:||||||.|.:.|:::..|||::|:|:|||.:.
  Fly   519 GDNKLVKVADFGLARLMRDDTYTAHAGAK-FPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATY 582

  Fly  1257 GDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVD 1315
            |.:||..:..:....::|.||||..|...|.|:|.||.|||..||..||.|..|::.::
  Fly   583 GMSPYPAIDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHALE 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	24/92 (26%)
		TyrKc	1063..1311	CDD:197581	108/255 (42%)
		PTKc_Fes_like	1067..1315	CDD:270637	109/255 (43%)
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784
		SH2_ABL	268..363	CDD:198189	23/95 (24%)
		PTKc_Abl	382..644	CDD:270645	112/268 (42%)
		Pkinase_Tyr	389..640	CDD:285015	109/258 (42%)
		FABD	1584..1723	CDD:197885
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468375
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D17578at33392
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	1	1.100	-	-	P	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.850