DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and fnbp1l

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_031755872.1	Gene:	fnbp1l / 448740	XenbaseID:	XB-GENE-489112	Length:	555	Species:	Xenopus tropicalis

Alignment Length:	532	Identity:	98/532 - (18%)
Similarity:	193/532 - (36%)	Gaps:	126/532 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 METMKRSIQMKAKCDKEYAISL-TAVAQQGLKIDRADEMQGSLISKSWRSYMDELDHQAKQFKFN 90
            ::...:.::.:.:.::.||..| ..|.:...|....||........|:.:.::||:..|.|.:..
Frog    25 LDKYAKFVKERLEIEQNYAKQLRNLVKKYCPKRSAKDEEPRFTSCLSFYNILNELNDYAGQREVV 89

  Fly    91 AEQL-EVVCDKLTHLSQDKRKARKAYQEEHAKIAARLNHLTDEVVRKKSEYQKHL-EGYKALRTR 153
            ||:: ..|..::...|.|.:..||::.:|..|....|:....::...|.::::.. |..||
Frog    90 AEEMGHRVYAEIMRYSNDIKGERKSHLQEGRKAQQYLDMCLKQMDNSKRKFERECREAEKA---- 150

  Fly   154 FEENYIKAPSRSGRKLDDVRDKYQKACRKLHL-TH------NEYVLSITE-AIEVEKDFRNVLLP 210
             ::.|.:..:.|.....||    :||.::||| ||      |||...:.. ..|..|.| .:::|
Frog   151 -QQTYERLDNDSNATKSDV----EKAKQQLHLRTHMADESKNEYAAQLQNYNAEQHKHF-YIVIP 209

  Fly   211 GLLEHQQSVQE-----------SFILLWRNILQEAAQYGDLTADKYKEIQKRIDTVI-------- 256
            .:.:|.|.:.|           .|....|.::...::..:......|.:.:|.|:.|
Frog   210 QVYKHLQEMDERRTVKLSECYKGFADAERKVIPIISKCLEGMVQAAKSVDERRDSQIVVDCFKSG 274

  Fly   257 ---GSINPTEEYGEFTEKYKTSPTTPLLFQFDETLIQD-------------IPGKLQSSTLTV-- 303
               ....|.|:|.:..  |:|.....:.....|:|..|             :.||....:|.:
Frog   275 FEPNGDYPFEDYSQHI--YRTVSDGTISTPKQESLKPDPRVTVGKAKGKLWLFGKKPKWSLRMGP 337

  Fly   304 -----DNLTVDWLRNRLQE-LEGAVRDCQEKQMKMIEHVNGGSPVANGSIISNGSNTSNGIQSN- 361
                 .:|..:..|.|||: ::...|:.| |:|...:.:|....|..       .|...|..|:
Frog   338 ALEDFSHLPPEQRRKRLQQRIDELSRELQ-KEMDQKDALNKMKDVYE-------KNPQMGDPSSL 394

  Fly   362 KDSLCRQSKDLNALRCQEKQKQKLVDMIKCALNEVGCEELPSGCDDDLTLEQNFIENGYNNEQQR 426
            ...:...:.::..||.:..:            ||....|               :|...:...:|
Frog   395 HPKIAETTSNIERLRMEIHK------------NEAWLSE---------------VEGKVSQRSER 432

  Fly   427 SNSTSSPGLGIMNELMRRGGVLTLLRGRGRHFKRKSTPQPATPMTRSRQGRFNKLQPRSQSLGSL 491
            .:|..:      |.|:.:|               :.:|:.:.....:::||   :||:..:....
Frog   433 RHSAEA------NHLVAQG---------------RESPEGSYTEDANQEGR---VQPQPHAHPEF 473

  Fly   492 SVIRDGNGPSPA 503
            ....|.:.|.||
Frog   474 DDEFDDDEPLPA 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341	49/237 (21%)
		SH2_Fps_family	953..1039	CDD:198224
		TyrKc	1063..1311	CDD:197581
		PTKc_Fes_like	1067..1315	CDD:270637
fnbp1l	XP_031755872.1	F-BAR_FNBP1L	5..256	CDD:153359	49/240 (20%)
		HR1_CIP4_FNBP1L	346..426	CDD:212018	19/114 (17%)
		SH3_FNBP1L	487..543	CDD:213005
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910