Protein Alignment FER and MST1R

DIOPT Version :10

• Sequence 1: NP_524288.3
• Gene: FER / 41118
• FlyBaseID: FBgn0000723
• Length: 1325
• Species: Drosophila melanogaster
• Sequence 2: XP_005265227.2
• Gene: MST1R / 4486
• HGNCID: 7381
• Length: 1401
• Species: Homo sapiens
• Alignment Length: 310
• Identity: 97/310 - (31%)
• Similarity: 164/310 - (52%)
• Gaps: 22/310 - (7%)

  Fly  1021 PFASIQELIMHQYHSELPVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAKL--- 1082
            |....:.:.:....|.|...||.  :|   :..||....:|.|     ||:|:||.||..:.
Human  1051 PLLRKESIQLRDLDSALLAEVKD--VL---IPHERVVTHSDRV-----IGKGHFGVVYHGEYIDQ 1105

  Fly  1083 KSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPI-MIVMELVLGGSL 1146
            ...::..|:|:.......:|...||:||.:::..:|||::.||||.:..:.: .:::..:..|.|
Human  1106 AQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVLALIGIMLPPEGLPHVLLPYMCHGDL 1170

  Fly  1147 LTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSRE-- 1209
            |.::|......|.:..:......|.||.||..:..:|||||||||::|...:||::|||::|:
Human  1171 LQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDIL 1235

  Fly  1210 EEEY--IVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARER 1272
            :.||  :......::||||.|.|:|...::|:..||||:|:|:||:.::|..||..:........
Human  1236 DREYYSVQQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHF 1300

  Fly  1273 IDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHF----DEIYNVVDALI 1318
            :..|.|:|.|:..|:.:|::|.|||.||...||.|    .|:..:|.||:
Human  1301 LAQGRRLPQPEYCPDSLYQVMQQCWEADPAVRPTFRVLVGEVEQIVSALL 1350

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	3/17 (18%)
		PTKc_Fes_like	1067..1315	CDD:270637	84/259 (32%)
MST1R	XP_005265227.2	Sema_RON	27..523	CDD:200540
		PSI	526..568	CDD:396154
		IPT_plexin_repeat1	569..683	CDD:238585
		IPT_plexin_repeat2	684..768	CDD:238584
		IPT	769..860	CDD:214657
		PTKc_Met_Ron	1087..1348	CDD:270649	86/265 (32%)