DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and MST1R

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_005265227.2	Gene:	MST1R / 4486	HGNCID:	7381	Length:	1401	Species:	Homo sapiens

Alignment Length:	310	Identity:	97/310 - (31%)
Similarity:	164/310 - (52%)	Gaps:	22/310 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly  1021 PFASIQELIMHQYHSELPVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAKL--- 1082
            |....:.:.:....|.|...||.  :|   :..||....:|.|     ||:|:||.||..:.
Human  1051 PLLRKESIQLRDLDSALLAEVKD--VL---IPHERVVTHSDRV-----IGKGHFGVVYHGEYIDQ 1105

  Fly  1083 KSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPI-MIVMELVLGGSL 1146
            ...::..|:|:.......:|...||:||.:::..:|||::.||||.:..:.: .:::..:..|.|
Human  1106 AQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVLALIGIMLPPEGLPHVLLPYMCHGDL 1170

  Fly  1147 LTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSRE-- 1209
            |.::|......|.:..:......|.||.||..:..:|||||||||::|...:||::|||::|:
Human  1171 LQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDIL 1235

  Fly  1210 EEEY--IVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARER 1272
            :.||  :......::||||.|.|:|...::|:..||||:|:|:||:.::|..||..:........
Human  1236 DREYYSVQQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHF 1300

  Fly  1273 IDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHF----DEIYNVVDALI 1318
            :..|.|:|.|:..|:.:|::|.|||.||...||.|    .|:..:|.||:
Human  1301 LAQGRRLPQPEYCPDSLYQVMQQCWEADPAVRPTFRVLVGEVEQIVSALL 1350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	3/17 (18%)
		TyrKc	1063..1311	CDD:197581	85/259 (33%)
		PTKc_Fes_like	1067..1315	CDD:270637	84/259 (32%)
MST1R	XP_005265227.2	Sema_RON	27..523	CDD:200540
		PSI	526..>565	CDD:279745
		IPT_plexin_repeat1	569..683	CDD:238585
		IPT_plexin_repeat2	684..768	CDD:238584
		IPT	769..860	CDD:214657
		TyrKc	1086..1339	CDD:197581	85/257 (33%)
		PTKc_Met_Ron	1087..1348	CDD:270649	86/265 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810